Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Nichole R. Klatt; Lauren A. Canary; Xiaoyong Sun; Carol L. Vinton; Nicholas T. Funderburg; David R. Morcock; Mariam Quiñones; Clayton B. Deming; Molly Perkins; Daria J. Hazuda; Michael D. Miller; Michael M. Lederman; Julie A. Segre; Jeffrey D. Lifson; Elias K. Haddad; Jacob D. Estes; Jason M. Brenchley

doi:10.1172/JCI66227

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Nichole R. Klatt, Lauren A. Canary, Xiaoyong Sun, Carol L. Vinton, Nicholas T. Funderburg, David R. Morcock, Mariam Quiñones, Clayton B. Deming, Molly Perkins, Daria J. Hazuda, Michael D. Miller, Michael M. Lederman, Julie A. Segre, Jeffrey D. Lifson, Elias K. Haddad, Jacob D. Estes, Jason M. Brenchley

Research output: Contribution to journal › Article › peer-review

134 Scopus citations

Abstract

HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4⁺ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.

Original language	English (US)
Pages (from-to)	903-907
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	123
Issue number	2
DOIs	https://doi.org/10.1172/JCI66227
State	Published - Feb 1 2013
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1172/JCI66227

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Klatt, N. R., Canary, L. A., Sun, X., Vinton, C. L., Funderburg, N. T., Morcock, D. R., Quiñones, M., Deming, C. B., Perkins, M., Hazuda, D. J., Miller, M. D., Lederman, M. M., Segre, J. A., Lifson, J. D., Haddad, E. K., Estes, J. D., & Brenchley, J. M. (2013). Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques. Journal of Clinical Investigation, 123(2), 903-907. https://doi.org/10.1172/JCI66227

Klatt, NR, Canary, LA, Sun, X, Vinton, CL, Funderburg, NT, Morcock, DR, Quiñones, M, Deming, CB, Perkins, M, Hazuda, DJ, Miller, MD, Lederman, MM, Segre, JA, Lifson, JD, Haddad, EK, Estes, JD & Brenchley, JM 2013, 'Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques', Journal of Clinical Investigation, vol. 123, no. 2, pp. 903-907. https://doi.org/10.1172/JCI66227

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title = "Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques",

abstract = "HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.",

author = "Klatt, {Nichole R.} and Canary, {Lauren A.} and Xiaoyong Sun and Vinton, {Carol L.} and Funderburg, {Nicholas T.} and Morcock, {David R.} and Mariam Qui{\~n}ones and Deming, {Clayton B.} and Molly Perkins and Hazuda, {Daria J.} and Miller, {Michael D.} and Lederman, {Michael M.} and Segre, {Julie A.} and Lifson, {Jeffrey D.} and Haddad, {Elias K.} and Estes, {Jacob D.} and Brenchley, {Jason M.}",

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AU - Klatt, Nichole R.

AU - Canary, Lauren A.

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AU - Vinton, Carol L.

AU - Funderburg, Nicholas T.

AU - Morcock, David R.

AU - Quiñones, Mariam

AU - Deming, Clayton B.

AU - Perkins, Molly

AU - Hazuda, Daria J.

AU - Miller, Michael D.

AU - Lederman, Michael M.

AU - Segre, Julie A.

AU - Lifson, Jeffrey D.

AU - Haddad, Elias K.

AU - Estes, Jacob D.

AU - Brenchley, Jason M.

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AB - HIV infection results in gastrointestinal (GI) tract damage, microbial translocation, and immune activation, which are not completely ameliorated with suppression of viremia by antiretroviral (ARV) therapy. Furthermore, increased morbidity and mortality of ARV-treated HIV-infected individuals is associated with these dysfunctions. Thus, to enhance GI tract physiology, we treated SIV-infected pigtail macaques with ARVs, probiotics, and prebiotics or with ARVs alone. This synbiotic treatment resulted in increased frequency and functionality of GI tract APCs, enhanced reconstitution and functionality of CD4+ T cells, and reduced fibrosis of lymphoid follicles in the colon. Thus, ARV synbiotic supplementation in HIV-infected individuals may improve GI tract immunity and thereby mitigate inflammatory sequelae, ultimately improving prognosis.

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Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques

Abstract

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