Principles of cryosurgery

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The mechanism by which a cryogen destroys cells is complex. The formation of a hemispherical iceball composed of thermogradients, each of which maintains a temperature proportional to its distance from the application point, initiates the cryoinjury. The cardinal rule of cryosurgery includes a rapid freeze, which produces highly damaging intracellular ice formation and closely-packed thermogradients, coupled with a slow thaw. Multiple freeze/thaw cycles are most destructive, producing ischemic necrosis. Histological and clinical aspects are discussed, as well as complications and follow-up procedures.

Original languageEnglish (US)
Pages (from-to)21-30
Number of pages10
JournalOphthalmic Surgery
Volume10
Issue number8
StatePublished - 1979
Externally publishedYes

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Cryosurgery
Ice
Necrosis
Temperature

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Principles of cryosurgery. / Wilkes, T. D I; Fraunfelder, Frederick (Fritz).

In: Ophthalmic Surgery, Vol. 10, No. 8, 1979, p. 21-30.

Research output: Contribution to journalArticle

Wilkes, TDI & Fraunfelder, FF 1979, 'Principles of cryosurgery', Ophthalmic Surgery, vol. 10, no. 8, pp. 21-30.
Wilkes, T. D I ; Fraunfelder, Frederick (Fritz). / Principles of cryosurgery. In: Ophthalmic Surgery. 1979 ; Vol. 10, No. 8. pp. 21-30.
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