Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA

Michael Comb; Peter H. Seeburg; John Adelman; Lee Eiden; Edward Herbert

doi:10.1038/295663a0

Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA

Michael Comb, Peter H. Seeburg, John Adelman, Lee Eiden, Edward Herbert

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Abstract

The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.

Original language	English (US)
Pages (from-to)	663-666
Number of pages	4
Journal	Nature
Volume	295
Issue number	5851
DOIs	https://doi.org/10.1038/295663a0
State	Published - 1982
Externally published	Yes

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title = "Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA",

abstract = "The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.",

author = "Michael Comb and Seeburg, {Peter H.} and John Adelman and Lee Eiden and Edward Herbert",

year = "1982",

doi = "10.1038/295663a0",

language = "English (US)",

volume = "295",

pages = "663--666",

journal = "Nature",

issn = "0028-0836",

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T1 - Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA

AU - Comb, Michael

AU - Seeburg, Peter H.

AU - Adelman, John

AU - Eiden, Lee

AU - Herbert, Edward

PY - 1982

Y1 - 1982

N2 - The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.

AB - The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.

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U2 - 10.1038/295663a0

DO - 10.1038/295663a0

M3 - Article

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AN - SCOPUS:0020036185

SN - 0028-0836

VL - 295

SP - 663

EP - 666

JO - Nature

JF - Nature

IS - 5851

ER -

Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA

Abstract

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