Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA

Michael Comb, Peter H. Seeburg, John Adelman, Lee Eiden, Edward Herbert

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Abstract

The nucleotide sequence of a complete cDNA copy of enkephalin precursor mRNA from human phaeochromocytoma is reported. The corresponding amino acid sequence shows that the precursor is 267 amino acids long and contains six interspersed Met-enkephalin sequences and one Leu-enkephalin sequence. Five of the seven enkephalins are flanked on both sides by pairs of basic amino acid residues. The precursor does not contain the sequences of the opioid peptides, dynorphin, α-neo-endorphin or β-endorphin.

Original languageEnglish (US)
Pages (from-to)663-666
Number of pages4
JournalNature
Volume295
Issue number5851
DOIs
StatePublished - Dec 1 1982

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    Comb, M., Seeburg, P. H., Adelman, J., Eiden, L., & Herbert, E. (1982). Primary structure of the human Met- And Leu-enkephalin precursor and its mRNA. Nature, 295(5851), 663-666. https://doi.org/10.1038/295663a0