Primary lung cancer: Biodistribution and dosimetry of two In-111-labeled monoclonal antibodies

P. H. Brown; G. T. Krishnamurthy; F. E. Turner; R. K. Denney; S. A. Gilbert; M. E. Slauson

doi:10.1148/radiology.173.3.2510212

Primary lung cancer: Biodistribution and dosimetry of two In-111-labeled monoclonal antibodies

P. H. Brown, G. T. Krishnamurthy, F. E. Turner, R. K. Denney, S. A. Gilbert, M. E. Slauson

Research output: Contribution to journal › Article › peer-review

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Abstract

This study was undertaken to measure the biokinetics and organ dosimetry of indium-111-labeled monoclonal antibodies (MoAbs) with a whole-body gamma camera imaging technique. Twenty patients with primary lung cancer were studied with two different MoAb agents (anti-carcinoembryonic antigen ZCE025 and antiadenocarcinoma LA20207). Imaging was performed at 1, 24, 72, and 144 hours after injection. Scintigraphic wholebody retention was verified by means of comparison with the results from in vitro counting of excreta. Organ retention was verified in an abdominal phantom. The MoAb cleared slowly from the heart and lungs, the brain and spleen showed no clearance, and the liver showed increased activity over the 6-day period. Dosimetry for ZCE025 showed a dose to the liver of 1.3 rad/mCi (0.36 mGy/MBq); heart, 1.5 rad/mCi (0.40 mGy/MBq); spleen, 1.1 rad/mCi (0.29 mGy/MBq); total body, 0.49 rad/mCi (0.13 mGy/MBq); and testes, 0.39 rad/mCi (0.11 mGy/MBq). The dosimetry for LA20207 was similar.

Original language	English (US)
Pages (from-to)	701-705
Number of pages	5
Journal	RADIOLOGY
Volume	173
Issue number	3
DOIs	https://doi.org/10.1148/radiology.173.3.2510212
State	Published - 1989
Externally published	Yes

Keywords

Lung neoplasms, radionuclide studies
Monoclonal antibodies
Radionuclide imaging, computer assisted
Radionuclide imaging, dosimetry
Radionuclide imaging, radiation dose

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiology.173.3.2510212

Cite this

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title = "Primary lung cancer: Biodistribution and dosimetry of two In-111-labeled monoclonal antibodies",

abstract = "This study was undertaken to measure the biokinetics and organ dosimetry of indium-111-labeled monoclonal antibodies (MoAbs) with a whole-body gamma camera imaging technique. Twenty patients with primary lung cancer were studied with two different MoAb agents (anti-carcinoembryonic antigen ZCE025 and antiadenocarcinoma LA20207). Imaging was performed at 1, 24, 72, and 144 hours after injection. Scintigraphic wholebody retention was verified by means of comparison with the results from in vitro counting of excreta. Organ retention was verified in an abdominal phantom. The MoAb cleared slowly from the heart and lungs, the brain and spleen showed no clearance, and the liver showed increased activity over the 6-day period. Dosimetry for ZCE025 showed a dose to the liver of 1.3 rad/mCi (0.36 mGy/MBq); heart, 1.5 rad/mCi (0.40 mGy/MBq); spleen, 1.1 rad/mCi (0.29 mGy/MBq); total body, 0.49 rad/mCi (0.13 mGy/MBq); and testes, 0.39 rad/mCi (0.11 mGy/MBq). The dosimetry for LA20207 was similar.",

keywords = "Lung neoplasms, radionuclide studies, Monoclonal antibodies, Radionuclide imaging, computer assisted, Radionuclide imaging, dosimetry, Radionuclide imaging, radiation dose",

author = "Brown, {P. H.} and Krishnamurthy, {G. T.} and Turner, {F. E.} and Denney, {R. K.} and Gilbert, {S. A.} and Slauson, {M. E.}",

year = "1989",

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AU - Brown, P. H.

AU - Krishnamurthy, G. T.

AU - Turner, F. E.

AU - Denney, R. K.

AU - Gilbert, S. A.

AU - Slauson, M. E.

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N2 - This study was undertaken to measure the biokinetics and organ dosimetry of indium-111-labeled monoclonal antibodies (MoAbs) with a whole-body gamma camera imaging technique. Twenty patients with primary lung cancer were studied with two different MoAb agents (anti-carcinoembryonic antigen ZCE025 and antiadenocarcinoma LA20207). Imaging was performed at 1, 24, 72, and 144 hours after injection. Scintigraphic wholebody retention was verified by means of comparison with the results from in vitro counting of excreta. Organ retention was verified in an abdominal phantom. The MoAb cleared slowly from the heart and lungs, the brain and spleen showed no clearance, and the liver showed increased activity over the 6-day period. Dosimetry for ZCE025 showed a dose to the liver of 1.3 rad/mCi (0.36 mGy/MBq); heart, 1.5 rad/mCi (0.40 mGy/MBq); spleen, 1.1 rad/mCi (0.29 mGy/MBq); total body, 0.49 rad/mCi (0.13 mGy/MBq); and testes, 0.39 rad/mCi (0.11 mGy/MBq). The dosimetry for LA20207 was similar.

AB - This study was undertaken to measure the biokinetics and organ dosimetry of indium-111-labeled monoclonal antibodies (MoAbs) with a whole-body gamma camera imaging technique. Twenty patients with primary lung cancer were studied with two different MoAb agents (anti-carcinoembryonic antigen ZCE025 and antiadenocarcinoma LA20207). Imaging was performed at 1, 24, 72, and 144 hours after injection. Scintigraphic wholebody retention was verified by means of comparison with the results from in vitro counting of excreta. Organ retention was verified in an abdominal phantom. The MoAb cleared slowly from the heart and lungs, the brain and spleen showed no clearance, and the liver showed increased activity over the 6-day period. Dosimetry for ZCE025 showed a dose to the liver of 1.3 rad/mCi (0.36 mGy/MBq); heart, 1.5 rad/mCi (0.40 mGy/MBq); spleen, 1.1 rad/mCi (0.29 mGy/MBq); total body, 0.49 rad/mCi (0.13 mGy/MBq); and testes, 0.39 rad/mCi (0.11 mGy/MBq). The dosimetry for LA20207 was similar.

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Primary lung cancer: Biodistribution and dosimetry of two In-111-labeled monoclonal antibodies

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