Prevalence of left heart contrast in healthy, young, asymptomatic humans at rest breathing room air

Jonathan E. Elliott, S. Milind Nigam, Steven S. Laurie, Kara M. Beasley, Randall D. Goodman, Jerold A. Hawn, Igor M. Gladstone, Mark S. Chesnutt, Andrew T. Lovering

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Our purpose was to report the prevalence of healthy, young, asymptomatic humans who demonstrate left heart contrast at rest, breathing room air. We evaluated 176 subjects (18-41 years old) using transthoracic saline contrast echocardiography. Left heart contrast appearing ≤3 cardiac cycles, consistent with a patent foramen ovale (PFO), was detected in 67 (38%) subjects. Left heart contrast appearing >3 cardiac cycles, consistent with the transpulmonary passage of contrast, was detected in 49 (28%) subjects. Of these 49 subjects, 31 were re-evaluated after breathing 100% O2 for 10-15min and 6 (19%) continued to demonstrate the transpulmonary passage of contrast. Additionally, 18 of these 49 subjects were re-evaluated in the upright position and 1 (5%) continued to demonstrate the transpulmonary passage of contrast. These data suggest that ~30% of healthy, young, asymptomatic subjects demonstrate the transpulmonary passage of contrast at rest which is reduced by breathing 100% O2 and assuming an upright body position.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume188
Issue number1
DOIs
StatePublished - Aug 1 2013

Keywords

  • Intrapulmonary arteriovenous anastomoses
  • Patent foramen ovale
  • Right-to-left shunt
  • Transthoracic saline contrast echocardiography

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine

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    Elliott, J. E., Nigam, S. M., Laurie, S. S., Beasley, K. M., Goodman, R. D., Hawn, J. A., Gladstone, I. M., Chesnutt, M. S., & Lovering, A. T. (2013). Prevalence of left heart contrast in healthy, young, asymptomatic humans at rest breathing room air. Respiratory Physiology and Neurobiology, 188(1), 71-78. https://doi.org/10.1016/j.resp.2013.04.019