Prevalence and natural history of neuropsychiatric syndromes in veteran hospice patients

Elizabeth R. Goy, Linda Ganzini

    Research output: Contribution to journalArticle

    11 Citations (Scopus)

    Abstract

    Context: Prospective studies are needed to adequately describe the overall impact of neuropsychiatric syndromes on the course of hospice enrollment in outpatient settings. Objectives: To determine the prevalence and natural history of delirium, cognitive impairment, alcohol abuse, anxiety, depression, and suicidal ideation (SI) in community-dwelling veteran hospice patients. Methods: Home hospice patients were visited regularly from enrollment until their deaths, study withdrawal, or discharge from hospice. Family caregivers gave consent for those with Mini-Mental State Examination (MMSE) scores less than or equal to 23. Measures included the Structured Clinical Interview for DSM-IV for depression (past and current) and alcohol abuse; the Hospital Anxiety and Depression Scale; MMSE; and Confusion Assessment Method (CAM). A clinician-rated CAM item documented sleep disturbance, and participants were asked about SI at each visit. Results: The median length of hospice enrollment was 81 days. Of 88 participants, 77 (88%) experienced at least one neuropsychiatric syndrome. Cognitive impairment was prevalent, with 60 (68%) registering MMSE less than or equal to 23 at least once. More than half of the participants developed delirium; the proportion with delirium, any cognitive impairment, sleep disturbance, or any neuropsychiatric syndrome increased significantly from first to last study visit. Twelve (14%) participants had SI during the study, and 30 (34%) participants were affected by depression overall. Sixteen patients who were not depressed on admission subsequently developed depression. Anxiety was present in 14 (16%) on at least one study visit. Active alcohol abuse remained relatively stable (8%) across visits. Conclusions: Psychiatric syndromes are highly prevalent in hospice patients. Systematic case finding of psychiatric disorders may be necessary to improve quality of life in the last months of life.

    Original languageEnglish (US)
    Pages (from-to)394-401
    Number of pages8
    JournalJournal of Pain and Symptom Management
    Volume41
    Issue number2
    DOIs
    StatePublished - Feb 2011

    Fingerprint

    Hospices
    Veterans
    Suicidal Ideation
    Delirium
    Depression
    Alcoholism
    Confusion
    Anxiety
    Psychiatry
    Sleep
    Independent Living
    Diagnostic and Statistical Manual of Mental Disorders
    Caregivers
    Outpatients
    Quality of Life
    Prospective Studies
    Interviews
    Cognitive Dysfunction

    Keywords

    • alcohol abuse
    • anxiety
    • delirium
    • depression
    • Hospice
    • insomnia
    • mental disorders
    • suicide
    • veterans

    ASJC Scopus subject areas

    • Anesthesiology and Pain Medicine
    • Clinical Neurology
    • Nursing(all)

    Cite this

    Prevalence and natural history of neuropsychiatric syndromes in veteran hospice patients. / Goy, Elizabeth R.; Ganzini, Linda.

    In: Journal of Pain and Symptom Management, Vol. 41, No. 2, 02.2011, p. 394-401.

    Research output: Contribution to journalArticle

    @article{fc705f6aa06f440288806ab65e76817e,
    title = "Prevalence and natural history of neuropsychiatric syndromes in veteran hospice patients",
    abstract = "Context: Prospective studies are needed to adequately describe the overall impact of neuropsychiatric syndromes on the course of hospice enrollment in outpatient settings. Objectives: To determine the prevalence and natural history of delirium, cognitive impairment, alcohol abuse, anxiety, depression, and suicidal ideation (SI) in community-dwelling veteran hospice patients. Methods: Home hospice patients were visited regularly from enrollment until their deaths, study withdrawal, or discharge from hospice. Family caregivers gave consent for those with Mini-Mental State Examination (MMSE) scores less than or equal to 23. Measures included the Structured Clinical Interview for DSM-IV for depression (past and current) and alcohol abuse; the Hospital Anxiety and Depression Scale; MMSE; and Confusion Assessment Method (CAM). A clinician-rated CAM item documented sleep disturbance, and participants were asked about SI at each visit. Results: The median length of hospice enrollment was 81 days. Of 88 participants, 77 (88{\%}) experienced at least one neuropsychiatric syndrome. Cognitive impairment was prevalent, with 60 (68{\%}) registering MMSE less than or equal to 23 at least once. More than half of the participants developed delirium; the proportion with delirium, any cognitive impairment, sleep disturbance, or any neuropsychiatric syndrome increased significantly from first to last study visit. Twelve (14{\%}) participants had SI during the study, and 30 (34{\%}) participants were affected by depression overall. Sixteen patients who were not depressed on admission subsequently developed depression. Anxiety was present in 14 (16{\%}) on at least one study visit. Active alcohol abuse remained relatively stable (8{\%}) across visits. Conclusions: Psychiatric syndromes are highly prevalent in hospice patients. Systematic case finding of psychiatric disorders may be necessary to improve quality of life in the last months of life.",
    keywords = "alcohol abuse, anxiety, delirium, depression, Hospice, insomnia, mental disorders, suicide, veterans",
    author = "Goy, {Elizabeth R.} and Linda Ganzini",
    year = "2011",
    month = "2",
    doi = "10.1016/j.jpainsymman.2010.04.015",
    language = "English (US)",
    volume = "41",
    pages = "394--401",
    journal = "Journal of Pain and Symptom Management",
    issn = "0885-3924",
    publisher = "Elsevier Inc.",
    number = "2",

    }

    TY - JOUR

    T1 - Prevalence and natural history of neuropsychiatric syndromes in veteran hospice patients

    AU - Goy, Elizabeth R.

    AU - Ganzini, Linda

    PY - 2011/2

    Y1 - 2011/2

    N2 - Context: Prospective studies are needed to adequately describe the overall impact of neuropsychiatric syndromes on the course of hospice enrollment in outpatient settings. Objectives: To determine the prevalence and natural history of delirium, cognitive impairment, alcohol abuse, anxiety, depression, and suicidal ideation (SI) in community-dwelling veteran hospice patients. Methods: Home hospice patients were visited regularly from enrollment until their deaths, study withdrawal, or discharge from hospice. Family caregivers gave consent for those with Mini-Mental State Examination (MMSE) scores less than or equal to 23. Measures included the Structured Clinical Interview for DSM-IV for depression (past and current) and alcohol abuse; the Hospital Anxiety and Depression Scale; MMSE; and Confusion Assessment Method (CAM). A clinician-rated CAM item documented sleep disturbance, and participants were asked about SI at each visit. Results: The median length of hospice enrollment was 81 days. Of 88 participants, 77 (88%) experienced at least one neuropsychiatric syndrome. Cognitive impairment was prevalent, with 60 (68%) registering MMSE less than or equal to 23 at least once. More than half of the participants developed delirium; the proportion with delirium, any cognitive impairment, sleep disturbance, or any neuropsychiatric syndrome increased significantly from first to last study visit. Twelve (14%) participants had SI during the study, and 30 (34%) participants were affected by depression overall. Sixteen patients who were not depressed on admission subsequently developed depression. Anxiety was present in 14 (16%) on at least one study visit. Active alcohol abuse remained relatively stable (8%) across visits. Conclusions: Psychiatric syndromes are highly prevalent in hospice patients. Systematic case finding of psychiatric disorders may be necessary to improve quality of life in the last months of life.

    AB - Context: Prospective studies are needed to adequately describe the overall impact of neuropsychiatric syndromes on the course of hospice enrollment in outpatient settings. Objectives: To determine the prevalence and natural history of delirium, cognitive impairment, alcohol abuse, anxiety, depression, and suicidal ideation (SI) in community-dwelling veteran hospice patients. Methods: Home hospice patients were visited regularly from enrollment until their deaths, study withdrawal, or discharge from hospice. Family caregivers gave consent for those with Mini-Mental State Examination (MMSE) scores less than or equal to 23. Measures included the Structured Clinical Interview for DSM-IV for depression (past and current) and alcohol abuse; the Hospital Anxiety and Depression Scale; MMSE; and Confusion Assessment Method (CAM). A clinician-rated CAM item documented sleep disturbance, and participants were asked about SI at each visit. Results: The median length of hospice enrollment was 81 days. Of 88 participants, 77 (88%) experienced at least one neuropsychiatric syndrome. Cognitive impairment was prevalent, with 60 (68%) registering MMSE less than or equal to 23 at least once. More than half of the participants developed delirium; the proportion with delirium, any cognitive impairment, sleep disturbance, or any neuropsychiatric syndrome increased significantly from first to last study visit. Twelve (14%) participants had SI during the study, and 30 (34%) participants were affected by depression overall. Sixteen patients who were not depressed on admission subsequently developed depression. Anxiety was present in 14 (16%) on at least one study visit. Active alcohol abuse remained relatively stable (8%) across visits. Conclusions: Psychiatric syndromes are highly prevalent in hospice patients. Systematic case finding of psychiatric disorders may be necessary to improve quality of life in the last months of life.

    KW - alcohol abuse

    KW - anxiety

    KW - delirium

    KW - depression

    KW - Hospice

    KW - insomnia

    KW - mental disorders

    KW - suicide

    KW - veterans

    UR - http://www.scopus.com/inward/record.url?scp=79951960055&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=79951960055&partnerID=8YFLogxK

    U2 - 10.1016/j.jpainsymman.2010.04.015

    DO - 10.1016/j.jpainsymman.2010.04.015

    M3 - Article

    C2 - 20869843

    AN - SCOPUS:79951960055

    VL - 41

    SP - 394

    EP - 401

    JO - Journal of Pain and Symptom Management

    JF - Journal of Pain and Symptom Management

    SN - 0885-3924

    IS - 2

    ER -