Presence of corticotropin releasing factor-like immunoreactivity in hypophysial portal blood.

D. M. Gibbs, W. Vale

Research output: Contribution to journalArticle

148 Citations (Scopus)

Abstract

Hypophysial protal blood was collected from pentobarbital anesthetized male rats, and the content of corticotropin releasing factor-like immunoreactivity (CRF-LI) was measured using an RIA developed for synthetic ovine CRF. The concentration of CRF-LI in portal plasma was 104.9 +/- 9.7 pM. This concentration is in the range which has been shown to stimulate ACTH and beta-endorphin secretion in vitro. These data support the hypothesis that a molecule with the same or similar structure as synthetic ovine CRF is a physiologically significant hypothalamic releasing factor.

Original languageEnglish (US)
Pages (from-to)1418-1420
Number of pages3
JournalEndocrinology
Volume111
Issue number4
StatePublished - Oct 1982

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Corticotropin-Releasing Hormone
Sheep
Pituitary Hormone-Releasing Hormones
beta-Endorphin
Pentobarbital
Adrenocorticotropic Hormone
In Vitro Techniques

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Presence of corticotropin releasing factor-like immunoreactivity in hypophysial portal blood. / Gibbs, D. M.; Vale, W.

In: Endocrinology, Vol. 111, No. 4, 10.1982, p. 1418-1420.

Research output: Contribution to journalArticle

Gibbs, D. M. ; Vale, W. / Presence of corticotropin releasing factor-like immunoreactivity in hypophysial portal blood. In: Endocrinology. 1982 ; Vol. 111, No. 4. pp. 1418-1420.
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