Presence op corticotropin releasing factor-like immunoreactivity in hypophysial portal blood

Daniel M. Gibbs, Wylie Vale

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Hypophysial portal blood was collected from pentobarbital anesthetized male rats, and the content of corticotropin releasing factor-like immunoreactivity (CRF-LI) was measured using an RIA developed for synthetic ovine CRP. The concentration of CRP-LI in portal plasma was 104-;9 ± 9.7 pM. This concentration is in the range which has been shown to stimulate ACTH and 8-endorphin secretion in vitro. These data support the hypothesis that a molecule with the same or similar structure as synthetic ovine CRP is a physiologically significant hypothalamic releasing factor.

Original languageEnglish (US)
Pages (from-to)1418-1420
Number of pages3
Issue number4
StatePublished - Oct 1982


ASJC Scopus subject areas

  • Endocrinology

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