Abstract
Hypophysial portal blood was collected from pentobarbital anesthetized male rats, and the content of corticotropin releasing factor-like immunoreactivity (CRF-LI) was measured using an RIA developed for synthetic ovine CRP. The concentration of CRP-LI in portal plasma was 104-;9 ± 9.7 pM. This concentration is in the range which has been shown to stimulate ACTH and 8-endorphin secretion in vitro. These data support the hypothesis that a molecule with the same or similar structure as synthetic ovine CRP is a physiologically significant hypothalamic releasing factor.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1418-1420 |
| Number of pages | 3 |
| Journal | Endocrinology |
| Volume | 111 |
| Issue number | 4 |
| DOIs | |
| State | Published - Oct 1982 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology