Preoperative Lateralization of ACTH-Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Venous Sinus Sampling

Edward H. Oldfield; George P. Chrousos; Heinrich M. Schulte; Marcus Schaaf; Paul E. McKeever; Adrian G. Krudy; Gordon B. Cutler; D. Lynn Loriaux; John L. Doppman

doi:10.1056/NEJM198501103120207

Preoperative Lateralization of ACTH-Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Venous Sinus Sampling

Edward H. Oldfield, George P. Chrousos, Heinrich M. Schulte, Marcus Schaaf, Paul E. McKeever, Adrian G. Krudy, Gordon B. Cutler, D. Lynn Loriaux, John L. Doppman

Research output: Contribution to journal › Article › peer-review

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Abstract

PREVIOUS reports have established the utility of selective catheterization of the inferior petrosal sinus for determination of plasma ACTH concentrations in the diagnosis of pituitary-dependent hypercortisolism.¹ ² ³ ⁴ ⁵ Preliminary studies suggest that hormonal secretion from a laterally located microadenoma drains preferentially into the ipsilateral inferior petrosal sinus.⁶ ⁷ ⁸ If this occurs consistently, simultaneous sampling of bilateral venous blood should provide a means of localizing the microadenoma in one side of the pituitary gland, aiding the surgeon's search for small lesions or, if the microadenoma cannot be found, allowing excision of the half of the gland containing the tumor. In this study we correlated…

Original language	English (US)
Pages (from-to)	100-103
Number of pages	4
Journal	New England Journal of Medicine
Volume	312
Issue number	2
DOIs	https://doi.org/10.1056/NEJM198501103120207
State	Published - Jan 10 1985
Externally published	Yes

ASJC Scopus subject areas

Medicine(all)

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Oldfield, E. H., Chrousos, G. P., Schulte, H. M., Schaaf, M., McKeever, P. E., Krudy, A. G., Cutler, G. B., Loriaux, D. L., & Doppman, J. L. (1985). Preoperative Lateralization of ACTH-Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Venous Sinus Sampling. New England Journal of Medicine, 312(2), 100-103. https://doi.org/10.1056/NEJM198501103120207

Oldfield, EH, Chrousos, GP, Schulte, HM, Schaaf, M, McKeever, PE, Krudy, AG, Cutler, GB, Loriaux, DL & Doppman, JL 1985, 'Preoperative Lateralization of ACTH-Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Venous Sinus Sampling', New England Journal of Medicine, vol. 312, no. 2, pp. 100-103. https://doi.org/10.1056/NEJM198501103120207

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abstract = "PREVIOUS reports have established the utility of selective catheterization of the inferior petrosal sinus for determination of plasma ACTH concentrations in the diagnosis of pituitary-dependent hypercortisolism.1 2 3 4 5 Preliminary studies suggest that hormonal secretion from a laterally located microadenoma drains preferentially into the ipsilateral inferior petrosal sinus.6 7 8 If this occurs consistently, simultaneous sampling of bilateral venous blood should provide a means of localizing the microadenoma in one side of the pituitary gland, aiding the surgeon's search for small lesions or, if the microadenoma cannot be found, allowing excision of the half of the gland containing the tumor. In this study we correlated…",

author = "Oldfield, {Edward H.} and Chrousos, {George P.} and Schulte, {Heinrich M.} and Marcus Schaaf and McKeever, {Paul E.} and Krudy, {Adrian G.} and Cutler, {Gordon B.} and Loriaux, {D. Lynn} and Doppman, {John L.}",

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AU - Oldfield, Edward H.

AU - Chrousos, George P.

AU - Schulte, Heinrich M.

AU - Schaaf, Marcus

AU - McKeever, Paul E.

AU - Krudy, Adrian G.

AU - Cutler, Gordon B.

AU - Loriaux, D. Lynn

AU - Doppman, John L.

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AB - PREVIOUS reports have established the utility of selective catheterization of the inferior petrosal sinus for determination of plasma ACTH concentrations in the diagnosis of pituitary-dependent hypercortisolism.1 2 3 4 5 Preliminary studies suggest that hormonal secretion from a laterally located microadenoma drains preferentially into the ipsilateral inferior petrosal sinus.6 7 8 If this occurs consistently, simultaneous sampling of bilateral venous blood should provide a means of localizing the microadenoma in one side of the pituitary gland, aiding the surgeon's search for small lesions or, if the microadenoma cannot be found, allowing excision of the half of the gland containing the tumor. In this study we correlated…

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Preoperative Lateralization of ACTH-Secreting Pituitary Microadenomas by Bilateral and Simultaneous Inferior Petrosal Venous Sinus Sampling

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