Pregnancy alters cardiac responsiveness to autonomic receptor agonists

P. M. Van Winkle, Virginia Brooks

Research output: Contribution to journalArticle

Abstract

Pregnancy alters baroreflex gain and range, but the mechanism of this change is not known. To determine if pregnancy alters the cardiac response to autonomie receptor stimulation we studied isolated buffer-perfused hearts from virgin (NP) and pregnant (P, 28 day gestation) rabbits, β-Adrenergic and cholinergic receptors were activated with isoproterenol (ISO, 0.3-300 nM) or acetylcholine (ACh, 0.310,000 μM). Drugs were infused in half-log increments and given in random order Hearts receiving ISO had cholinergic blockade with atropine (5 μM), and hearts receiving ACh had βadrenergic blockade with propranolol (1 nM). All hearts had aadrenergic blockade with phenoxybenzamine (10 nM). ISO caused a dose-dependent increase in heart rate; this relationship was shifted leftward 1 log order in P hearts as compared to NP hearts. Conversely, ACh caused a dosedependent decrease in heart rate; this relationship was shifted rightward Vi log order in P hearts as compared NP hearts. We conclude that pregnancy augments the cardiac response to β-adrenergic receptor activation and diminishes the cardiac response to cholinergic receptor activation.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

agonists
heart
pregnancy
Pregnancy
receptors
cholinergic receptors
adrenergic receptors
Cholinergic Receptors
Adrenergic Receptors
heart rate
phenoxybenzamine
Heart Rate
Phenoxybenzamine
propranolol
Chemical activation
Baroreflex
cholinergic agents
atropine
acetylcholine
Atropine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

Pregnancy alters cardiac responsiveness to autonomic receptor agonists. / Van Winkle, P. M.; Brooks, Virginia.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

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