Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment

Kenneth D. Youngren, Bita Moghaddam, Benjamin S. Bunney, Robert H. Roth

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalNeuroscience Letters
Volume165
Issue number1-2
DOIs
StatePublished - Jan 3 1994
Externally publishedYes

Fingerprint

Clozapine
Prefrontal Cortex
Dopamine
Nucleus Accumbens
Microdialysis
Drinking Water
Brain

Keywords

  • Clozapine
  • Dopamine
  • Microdialysis
  • Nucleus accumbens
  • Prefrontal cortex
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. / Youngren, Kenneth D.; Moghaddam, Bita; Bunney, Benjamin S.; Roth, Robert H.

In: Neuroscience Letters, Vol. 165, No. 1-2, 03.01.1994, p. 41-44.

Research output: Contribution to journalArticle

Youngren, Kenneth D. ; Moghaddam, Bita ; Bunney, Benjamin S. ; Roth, Robert H. / Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment. In: Neuroscience Letters. 1994 ; Vol. 165, No. 1-2. pp. 41-44.
@article{17827be840654bce8d0b4860786361bc,
title = "Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment",
abstract = "The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.",
keywords = "Clozapine, Dopamine, Microdialysis, Nucleus accumbens, Prefrontal cortex, Striatum",
author = "Youngren, {Kenneth D.} and Bita Moghaddam and Bunney, {Benjamin S.} and Roth, {Robert H.}",
year = "1994",
month = "1",
day = "3",
doi = "10.1016/0304-3940(94)90704-8",
language = "English (US)",
volume = "165",
pages = "41--44",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

TY - JOUR

T1 - Preferential activation of dopamine overflow in prefrontal cortex produced by chronic clozapine treatment

AU - Youngren, Kenneth D.

AU - Moghaddam, Bita

AU - Bunney, Benjamin S.

AU - Roth, Robert H.

PY - 1994/1/3

Y1 - 1994/1/3

N2 - The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

AB - The effect of chronic treatment with clozapine on extracellular dopamine levels in the rat striatum, nucleus accumbens and medial prefrontal cortex (mPFC) was examined using intracerebral microdialysis. Clozapine (20 mg/kg/day × 21 days in drinking water) increased basal dopamine release in the mPFC but had no effect in the striatum or nucleus accumbens. After chronic treatment, an acute dose of clozapine (20 mg/kg i.p.) produced large and long-lasting increases in extracellular dopamine in all three brain regions. The data suggest that chronic clozapine produces a sustained enhancement in dopaminergic tone in the mPFC.

KW - Clozapine

KW - Dopamine

KW - Microdialysis

KW - Nucleus accumbens

KW - Prefrontal cortex

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=0027972670&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027972670&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(94)90704-8

DO - 10.1016/0304-3940(94)90704-8

M3 - Article

C2 - 8015734

AN - SCOPUS:0027972670

VL - 165

SP - 41

EP - 44

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1-2

ER -