Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis

M. Margaretten, E. Yelin, J. Imboden, J. Graf, Jennifer Barton, P. Katz, L. Julian

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

Objective. Patients with rheumatoid arthritis (RA) who experience depression have worse health outcomes. This study identifies predictors of depression in an ethnically and racially diverse population of patients with RA. Methods. Patients with RA in a prospective cohort at the San Francisco General Hospital outpatient rheumatology clinic were included if they were age ≥18 years, met the American College of Rheumatology classification criteria for RA, had a Health Assessment Questionnaire (HAQ) score collected, and had the RA-specific Disease Activity Score performed by a rheumatologist. The outcome variable was a depression score measured by the Patient Health Questionnaire 9 (PHQ-9), a self-report questionnaire validated to correlate with a diagnosis of major depression. Results. Three hundred forty-nine clinical visits for 172 patients were included in the analysis. Forty percent of patients scored ≥10 on the PHQ-9 during at least one clinic visit, which corresponds to a symptom severity of at least moderate depression. The mean PHQ-9 score was 7, corresponding to a symptom severity of mild depression. In the multivariate analysis, higher HAQ scores were associated with depression, and Asians had lower depression scores compared with Hispanic, white, and African American subjects. Conclusion. Identifying associated predictors of depression in a diverse population of patients with RA can help guide treatment, which should include preventing disability and decreased function as well as targeting depressive symptoms more specifically in patients with RA.

Original languageEnglish (US)
Pages (from-to)1586-1591
Number of pages6
JournalArthritis Care and Research
Volume61
Issue number11
DOIs
StatePublished - Nov 15 2009
Externally publishedYes

Fingerprint

Rheumatoid Arthritis
Depression
Health
Hospital Outpatient Clinics
San Francisco
Rheumatology
Ambulatory Care
Hispanic Americans
General Hospitals
African Americans
Self Report
Population
Surveys and Questionnaires
Multivariate Analysis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. / Margaretten, M.; Yelin, E.; Imboden, J.; Graf, J.; Barton, Jennifer; Katz, P.; Julian, L.

In: Arthritis Care and Research, Vol. 61, No. 11, 15.11.2009, p. 1586-1591.

Research output: Contribution to journalArticle

Margaretten, M, Yelin, E, Imboden, J, Graf, J, Barton, J, Katz, P & Julian, L 2009, 'Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis', Arthritis Care and Research, vol. 61, no. 11, pp. 1586-1591. https://doi.org/10.1002/art.24822
Margaretten, M. ; Yelin, E. ; Imboden, J. ; Graf, J. ; Barton, Jennifer ; Katz, P. ; Julian, L. / Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis. In: Arthritis Care and Research. 2009 ; Vol. 61, No. 11. pp. 1586-1591.
@article{3c93a30714cc483ab646f8aa106c8f55,
title = "Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis",
abstract = "Objective. Patients with rheumatoid arthritis (RA) who experience depression have worse health outcomes. This study identifies predictors of depression in an ethnically and racially diverse population of patients with RA. Methods. Patients with RA in a prospective cohort at the San Francisco General Hospital outpatient rheumatology clinic were included if they were age ≥18 years, met the American College of Rheumatology classification criteria for RA, had a Health Assessment Questionnaire (HAQ) score collected, and had the RA-specific Disease Activity Score performed by a rheumatologist. The outcome variable was a depression score measured by the Patient Health Questionnaire 9 (PHQ-9), a self-report questionnaire validated to correlate with a diagnosis of major depression. Results. Three hundred forty-nine clinical visits for 172 patients were included in the analysis. Forty percent of patients scored ≥10 on the PHQ-9 during at least one clinic visit, which corresponds to a symptom severity of at least moderate depression. The mean PHQ-9 score was 7, corresponding to a symptom severity of mild depression. In the multivariate analysis, higher HAQ scores were associated with depression, and Asians had lower depression scores compared with Hispanic, white, and African American subjects. Conclusion. Identifying associated predictors of depression in a diverse population of patients with RA can help guide treatment, which should include preventing disability and decreased function as well as targeting depressive symptoms more specifically in patients with RA.",
author = "M. Margaretten and E. Yelin and J. Imboden and J. Graf and Jennifer Barton and P. Katz and L. Julian",
year = "2009",
month = "11",
day = "15",
doi = "10.1002/art.24822",
language = "English (US)",
volume = "61",
pages = "1586--1591",
journal = "Arthritis and Rheumatology",
issn = "2326-5191",
publisher = "John Wiley and Sons Ltd",
number = "11",

}

TY - JOUR

T1 - Predictors of depression in a multiethnic cohort of patients with rheumatoid arthritis

AU - Margaretten, M.

AU - Yelin, E.

AU - Imboden, J.

AU - Graf, J.

AU - Barton, Jennifer

AU - Katz, P.

AU - Julian, L.

PY - 2009/11/15

Y1 - 2009/11/15

N2 - Objective. Patients with rheumatoid arthritis (RA) who experience depression have worse health outcomes. This study identifies predictors of depression in an ethnically and racially diverse population of patients with RA. Methods. Patients with RA in a prospective cohort at the San Francisco General Hospital outpatient rheumatology clinic were included if they were age ≥18 years, met the American College of Rheumatology classification criteria for RA, had a Health Assessment Questionnaire (HAQ) score collected, and had the RA-specific Disease Activity Score performed by a rheumatologist. The outcome variable was a depression score measured by the Patient Health Questionnaire 9 (PHQ-9), a self-report questionnaire validated to correlate with a diagnosis of major depression. Results. Three hundred forty-nine clinical visits for 172 patients were included in the analysis. Forty percent of patients scored ≥10 on the PHQ-9 during at least one clinic visit, which corresponds to a symptom severity of at least moderate depression. The mean PHQ-9 score was 7, corresponding to a symptom severity of mild depression. In the multivariate analysis, higher HAQ scores were associated with depression, and Asians had lower depression scores compared with Hispanic, white, and African American subjects. Conclusion. Identifying associated predictors of depression in a diverse population of patients with RA can help guide treatment, which should include preventing disability and decreased function as well as targeting depressive symptoms more specifically in patients with RA.

AB - Objective. Patients with rheumatoid arthritis (RA) who experience depression have worse health outcomes. This study identifies predictors of depression in an ethnically and racially diverse population of patients with RA. Methods. Patients with RA in a prospective cohort at the San Francisco General Hospital outpatient rheumatology clinic were included if they were age ≥18 years, met the American College of Rheumatology classification criteria for RA, had a Health Assessment Questionnaire (HAQ) score collected, and had the RA-specific Disease Activity Score performed by a rheumatologist. The outcome variable was a depression score measured by the Patient Health Questionnaire 9 (PHQ-9), a self-report questionnaire validated to correlate with a diagnosis of major depression. Results. Three hundred forty-nine clinical visits for 172 patients were included in the analysis. Forty percent of patients scored ≥10 on the PHQ-9 during at least one clinic visit, which corresponds to a symptom severity of at least moderate depression. The mean PHQ-9 score was 7, corresponding to a symptom severity of mild depression. In the multivariate analysis, higher HAQ scores were associated with depression, and Asians had lower depression scores compared with Hispanic, white, and African American subjects. Conclusion. Identifying associated predictors of depression in a diverse population of patients with RA can help guide treatment, which should include preventing disability and decreased function as well as targeting depressive symptoms more specifically in patients with RA.

UR - http://www.scopus.com/inward/record.url?scp=70449513693&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70449513693&partnerID=8YFLogxK

U2 - 10.1002/art.24822

DO - 10.1002/art.24822

M3 - Article

C2 - 19877099

AN - SCOPUS:70449513693

VL - 61

SP - 1586

EP - 1591

JO - Arthritis and Rheumatology

JF - Arthritis and Rheumatology

SN - 2326-5191

IS - 11

ER -