Predictive value of testing nasopharyngeal samples for respiratory viruses in the setting of lower respiratory tract disease

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Abstract

To determine the predictive value of nasopharyngeal (NP) sample testing for respiratory viruses (RVs) in suspected lower respiratory tract disease, 72 paired NP and bronchoalveolar lavage (BAL) fluid specimen sets, mostly from transplant recipients or patients with hematologic malignancies, were analyzed. Overall, 31.3% of the specimens tested positive for an RV. In 19 sets (26.4%), the NP and BAL fluid specimens were both positive for an RV; in 3 sets (4.2%), the NP specimens were positive but the BAL fluid specimens were negative; and in 3 other sets, the NP specimens were negative but the BAL fluid specimens were positive. The positive and negative predictive values of the NP specimens were 86.4% and 94%, respectively.

Original languageEnglish (US)
Pages (from-to)4020-4022
Number of pages3
JournalJournal of Clinical Microbiology
Volume52
Issue number11
DOIs
StatePublished - Nov 1 2014

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Respiratory Tract Diseases
Bronchoalveolar Lavage Fluid
Viruses
Hematologic Neoplasms

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

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title = "Predictive value of testing nasopharyngeal samples for respiratory viruses in the setting of lower respiratory tract disease",
abstract = "To determine the predictive value of nasopharyngeal (NP) sample testing for respiratory viruses (RVs) in suspected lower respiratory tract disease, 72 paired NP and bronchoalveolar lavage (BAL) fluid specimen sets, mostly from transplant recipients or patients with hematologic malignancies, were analyzed. Overall, 31.3{\%} of the specimens tested positive for an RV. In 19 sets (26.4{\%}), the NP and BAL fluid specimens were both positive for an RV; in 3 sets (4.2{\%}), the NP specimens were positive but the BAL fluid specimens were negative; and in 3 other sets, the NP specimens were negative but the BAL fluid specimens were positive. The positive and negative predictive values of the NP specimens were 86.4{\%} and 94{\%}, respectively.",
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AB - To determine the predictive value of nasopharyngeal (NP) sample testing for respiratory viruses (RVs) in suspected lower respiratory tract disease, 72 paired NP and bronchoalveolar lavage (BAL) fluid specimen sets, mostly from transplant recipients or patients with hematologic malignancies, were analyzed. Overall, 31.3% of the specimens tested positive for an RV. In 19 sets (26.4%), the NP and BAL fluid specimens were both positive for an RV; in 3 sets (4.2%), the NP specimens were positive but the BAL fluid specimens were negative; and in 3 other sets, the NP specimens were negative but the BAL fluid specimens were positive. The positive and negative predictive values of the NP specimens were 86.4% and 94%, respectively.

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