Prediction of bone marrow iron findings from tests performed on peripheral blood

D. L. Witte, Dale Kraemer, G. F. Johnson, F. R. Dick, H. Hamilton

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

After evaluating multiple tests, the authors have devised a scheme to predict bone marrow iron findings from tests performed on peripheral blood. They examined bone marrows from 97 consecutive patients with anemia who were divided into five marrow morphologic groups: ( 1) iron deficiency; (2) anemia of chronic disease; (3) abnormal sideroblasts; (4) ring sideroblasts; and (5) other. Tests of peripheral blood included hemoglobin, hematocrit, red blood cell count and red blood cell indices, reticulocyte count, sedimentation rate or zetacrit, ferritin, iron, iron binding capacity, free erythrocyte protoporphyrin, and tests of hepatic and renal function. Cluster analysis, multidimensional scaling, and logistic discriminant analysis were used to derive a graph of serum ferritin with the sedimentation rate, allowing accurate confirmation or exclusion of iron deficiency in most patients. Percent saturation of serum transferrin and serum ferritin allowed identification of only 50 percent of patients with abnormal or ring sideroblasts while excluding 100 percent of patients without abnormal or ring sideroblasts. In three years of follow-up, two of 19 patients with abnormal or ring sideroblast have developed the dysmyelopoietic syndrome or ANLL, respectively. With the aid of the two parameter graphs described, the authors believe the differential diagnosis of the hypoproliferative anemias relating to iron metabolism can frequently be made without examination of the bone marrow.

Original languageEnglish (US)
Pages (from-to)202-206
Number of pages5
JournalAmerican journal of clinical pathology
Volume85
Issue number2
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Iron
Bone Marrow
Ferritins
Anemia
Erythrocytes
Serum
Bone Marrow Examination
Reticulocyte Count
Erythrocyte Count
Erythrocyte Indices
Myelodysplastic Syndromes
Hematologic Tests
Discriminant Analysis
Transferrin
Hematocrit
Acute Myeloid Leukemia
Cluster Analysis
Hemoglobins
Differential Diagnosis
Chronic Disease

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Prediction of bone marrow iron findings from tests performed on peripheral blood. / Witte, D. L.; Kraemer, Dale; Johnson, G. F.; Dick, F. R.; Hamilton, H.

In: American journal of clinical pathology, Vol. 85, No. 2, 01.01.1986, p. 202-206.

Research output: Contribution to journalArticle

Witte, D. L. ; Kraemer, Dale ; Johnson, G. F. ; Dick, F. R. ; Hamilton, H. / Prediction of bone marrow iron findings from tests performed on peripheral blood. In: American journal of clinical pathology. 1986 ; Vol. 85, No. 2. pp. 202-206.
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