Predicting the rate of cognitive decline in aging and early Alzheimer disease

S. Adak, K. Illouz, W. Gorman, R. Tandon, E. A. Zimmerman, R. Guariglia, M. M. Moore, Jeffrey Kaye

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

Objectives: To determine prognostic factors affecting the course of Alzheimer disease (AD) and to determine the role of region-specific brain volumes as predictors of cognitive decline. Methods: Longitudinal data from 166 normal elderly individuals and 59 early AD patients were analyzed. Brain volumes were extracted from MRI scans using semiautomated recursive segmentation methods. Prognostic factors were considered significant if they had a significant effect on the rate of cognitive decline. Results: In multivariate analysis, higher Clinical Dementia Rating Scale (CDR) score at entry was a significant prognostic factor for an increased rate of cognitive decline. Significant prognostic factors within the baseline CDR = 0 group were base rate of progression and percent total high signal intensity (HSI), percent ventricular, and percent CSF volumes. Base rate of progression, family history, and percent ventricular volume were significant prognostic factors within the CDR = 0.5 group and APOE had a marginally significant effect on the rate of cognitive decline in the CDR = 1 group. Conclusions: Percent total HSI, ventricular, and total CSF volume measures can independently predict the rate of cognitive decline and improve the predictive power of statistical models that use only clinical data. Brain volumetric measures from MRI can be used to estimate the rate of cognitive decline even among normal elderly individuals and thus may aid in the prediction of time of onset of disease.

Original languageEnglish (US)
Pages (from-to)108-114
Number of pages7
JournalNeurology
Volume63
Issue number1
StatePublished - Jul 13 2004

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Alzheimer Disease
Dementia
Brain
Statistical Models
Cognitive Dysfunction
Multivariate Analysis
Magnetic Resonance Imaging

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Adak, S., Illouz, K., Gorman, W., Tandon, R., Zimmerman, E. A., Guariglia, R., ... Kaye, J. (2004). Predicting the rate of cognitive decline in aging and early Alzheimer disease. Neurology, 63(1), 108-114.

Predicting the rate of cognitive decline in aging and early Alzheimer disease. / Adak, S.; Illouz, K.; Gorman, W.; Tandon, R.; Zimmerman, E. A.; Guariglia, R.; Moore, M. M.; Kaye, Jeffrey.

In: Neurology, Vol. 63, No. 1, 13.07.2004, p. 108-114.

Research output: Contribution to journalArticle

Adak, S, Illouz, K, Gorman, W, Tandon, R, Zimmerman, EA, Guariglia, R, Moore, MM & Kaye, J 2004, 'Predicting the rate of cognitive decline in aging and early Alzheimer disease', Neurology, vol. 63, no. 1, pp. 108-114.
Adak S, Illouz K, Gorman W, Tandon R, Zimmerman EA, Guariglia R et al. Predicting the rate of cognitive decline in aging and early Alzheimer disease. Neurology. 2004 Jul 13;63(1):108-114.
Adak, S. ; Illouz, K. ; Gorman, W. ; Tandon, R. ; Zimmerman, E. A. ; Guariglia, R. ; Moore, M. M. ; Kaye, Jeffrey. / Predicting the rate of cognitive decline in aging and early Alzheimer disease. In: Neurology. 2004 ; Vol. 63, No. 1. pp. 108-114.
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