Precocious Puberty Associated With Neurofibromatosis and Optic Gliomas: Treatment With Luteinizing Hormone Releasing Hormone Analogue

Louisa Laue, Florence Comite, Karen Hench, D. Lynn Loriaux, Gordon B. Cutler, Ora Hirsch Pescovitz

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Seven children with central precocious puberty and either neurofibromatosis and/or optic gliomas were referred to the National Institutes of Health, Bethesda, Md, for evaluation and treatment with the long-acting luteinizing hormone releasing hormone analogue D-Trp6-Pro9-NEt-LHRH. Only six of the seven children chose to receive treatment. Four children presented with neurofibromatosis, three of whom also had optic gliomas; the remaining three children had isolated optic gliomas, without other neurocutaneous stigmas. All had central precocious puberty mediated by activation of the hypothalamic-pituitary-gonadal axis. Six months of LHRH, therapy caused suppression of gonadotropin and sex steroid levels, stabilization or regression of secondary sexual characteristics, and decreases in growth velocity and the rate of bone age maturation. We conclude that LHRH, therapy is effective in the treatment of central precocious puberty secondary to neurofibromatosis and/or optic gliomas.

Original languageEnglish (US)
Pages (from-to)1097-1100
Number of pages4
JournalAmerican Journal of Diseases of Children
Issue number11
StatePublished - Nov 1985


ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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