Preclinical studies of alcohol binge drinking

John Jr Crabbe, R. Adron Harris, George F. Koob

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Binge drinking is prevalent and has serious biomedical consequences. In children, adolescents, and young adults, it is a prominent risk factor for later development of alcohol-use disorders. Many preclinical models have been employed to study the genetic risks for and biomedical consequences of alcohol drinking. However, these models historically did not result in blood-alcohol concentrations (BACs) exceeding 80 mg%; this relatively modest level is the threshold that currently defines a binge session, according to the NIAAA and CDC. Nevertheless, in alcohol-dependent rodents, binge drinking has been well documented. Key neurobiological substrates localized to brain reward and stress systems have been identified. Studies of newer models of binge drinking without dependence are reviewed here. In these models, rodents, non-human primates, and flies will drink enough to reach high BACs. They often display observable signs of intoxication. The neurobiological consequences of these episodes of binge drinking without dependence are reviewed, and preliminary evidence for roles for GABA, glutamate, opioid peptides, and corticotropin releasing factor are discussed, as is the need for more work to identify the antecedents and consequences of binge drinking in both animal models and humans.

Original languageEnglish (US)
Pages (from-to)24-40
Number of pages17
JournalAnnals of the New York Academy of Sciences
Volume1216
Issue number1
DOIs
StatePublished - Jan 2011

Fingerprint

Binge Drinking
Alcohol Drinking
Alcohols
Rodentia
National Institute on Alcohol Abuse and Alcoholism (U.S.)
Blood
Opioid Peptides
Corticotropin-Releasing Hormone
Centers for Disease Control and Prevention (U.S.)
Reward
Diptera
gamma-Aminobutyric Acid
Primates
Glutamic Acid
Young Adult
Brain
Animals
Animal Models
Alcohol
Substrates

Keywords

  • Alcohol
  • Animal models
  • Binge drinking
  • Intoxication

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Preclinical studies of alcohol binge drinking. / Crabbe, John Jr; Harris, R. Adron; Koob, George F.

In: Annals of the New York Academy of Sciences, Vol. 1216, No. 1, 01.2011, p. 24-40.

Research output: Contribution to journalArticle

Crabbe, John Jr ; Harris, R. Adron ; Koob, George F. / Preclinical studies of alcohol binge drinking. In: Annals of the New York Academy of Sciences. 2011 ; Vol. 1216, No. 1. pp. 24-40.
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