Preclinical data on co-delivery of temozolomide and talazoparib by fucodain-coated nanoscale metal organic frameworks for colorectal cancer chemoradiation

Allison N. DuRoss, Madeleine R. Landry, Charles R. Thomas, Megan J. Neufeld, Conroy Sun

Research output: Contribution to journalArticlepeer-review

Abstract

Nanoparticle characterization and in vitro data on the effects of combined PARP inhibition and DNA damage by chemoradiation are shown. This data accompanies the research article “Fucoidan-coated nanoparticles target radiation-induced P-selectin to enhance chemoradiotherapy in murine colorectal cancer” (DuRoss et al., 2021) Additional characterization of the physiochemical properties of nanoscale metal organic frameworks (nMOFs) comprised of hafnium and 1,4-dicarboxybenzene (Hf-BDC) loaded with temozolomide (TMZ) and talazoparib (Tal) are presented. Toxicity data of the drug-loaded nMOF coated with fucoidan (TT@Hf-BDC-Fuco) in colorectal cancer cells, CT-26, from alamarBlue-based chemoradiation experiments are shown. Experimental methods for the nanoparticle characterization and cell-based assays of the nMOF formulation are presented.

Original languageEnglish (US)
Article number107394
JournalData in Brief
Volume38
DOIs
StatePublished - Oct 2021

Keywords

  • DNA Damage
  • MOF
  • Nanomedicine
  • PARP
  • Radiation therapy

ASJC Scopus subject areas

  • General

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