Pre-transplant comorbidity burden and post-transplant chronic graft-versus-host disease

Jennifer E. Vaughn, Ted Gooley, Richard T. Maziarz, Michael A. Pulsipher, Smita Bhatia, David G. Maloney, Brenda M. Sandmaier, Mary E. Flowers, Rainer Storb, Mohamed L. Sorror

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The Haematopoietic Cell Transplantation-Comorbidity Index (HCT-CI) was designed as a predictor of non-relapse mortality after HCT. Chronic graft-versus-host disease (GVHD) contributes to mortality after HCT. Here, we investigated whether the HCT-CI could predict development of chronic GVHD or post-chronic GVHD mortality. We retrospectively analysed data from 2909 patients treated with allogeneic HCT for malignant and non-malignant haematological conditions at four institutions. In Cox regression models adjusted for potential confounders, increasing HCT-CI was not statistically significantly associated with the development of chronic GVHD [hazard ratio (HR) = 1·02, P = 0·34]. Yet, the index was associated with an increased risk of non-relapse mortality (HR = 1·29, P < 0·0001) as well as overall mortality (HR = 1·25, P < 0·001) following the development of chronic GVHD. The association between HCT-CI and post-chronic GVHD mortality was similar regardless of donor type or stem cell source. HCT-CI scores could be incorporated in the design of clinical trials for treatment of chronic GVHD.

Original languageEnglish (US)
Pages (from-to)411-416
Number of pages6
JournalBritish Journal of Haematology
Volume171
Issue number3
DOIs
StatePublished - Nov 2015

Keywords

  • Graft-versus-host disease
  • Haematopoietic Cell Transplantation-Comorbidity Index
  • Haematopoietic stem cells
  • Non-relapse mortality after HCT
  • Transplantation

ASJC Scopus subject areas

  • Hematology

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