Pre- and postsynaptic factors influencing the neural encoding of afferent baroreceptor activity in the rat

J. H. Schild, J. W. Clark, Michael Andresen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The processing of baroreceptor activity by neurons within the dorsomedial region of the nucleus of the tractus solitarius (mNTS) is essential to neural circulatory control. Here, we are investigating the dynamic characteristics of mNTS neurons in response to activation patterns that are typical of both myelinated (A-type) and unmyelinated (C-type) baroreceptor fibers. Also examined is the relative balance between pre- and postsynaptic mechanisms that may underlie the neural integration of barosensory signals. This is accomplished using a comprehensive model of this first synapse in the baroreflex pathway. In addition to reproducing a wide variety of experimental data, we investigate how such use-dependent properties as vesicular mobilization, postsynaptic receptor desensitization and the nonlinear dynamics of mNTS neurons can effect the encoding of synaptic activity in spontaneously active mNTS cells. We demonstrate that because of the intrinsic dynamics of this sensory afferent synapse, C-type baroreceptors may have a more pronounced and sustained influence upon mNTS neurons than A-type. This work is part of a continuing collaborative effort investigating the neural integration of the broad spectrum of barosensory information arriving at the mNTS.

Original languageEnglish (US)
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Editors Anon
Pages1369-1370
Number of pages2
Volume17
Edition2
StatePublished - 1995
EventProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can
Duration: Sep 20 1995Sep 23 1995

Other

OtherProceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2)
CityMontreal, Can
Period9/20/959/23/95

Fingerprint

Neurons
Rats
Chemical activation
Fibers
Processing

ASJC Scopus subject areas

  • Bioengineering

Cite this

Schild, J. H., Clark, J. W., & Andresen, M. (1995). Pre- and postsynaptic factors influencing the neural encoding of afferent baroreceptor activity in the rat. In Anon (Ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings (2 ed., Vol. 17, pp. 1369-1370)

Pre- and postsynaptic factors influencing the neural encoding of afferent baroreceptor activity in the rat. / Schild, J. H.; Clark, J. W.; Andresen, Michael.

Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. ed. / Anon. Vol. 17 2. ed. 1995. p. 1369-1370.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Schild, JH, Clark, JW & Andresen, M 1995, Pre- and postsynaptic factors influencing the neural encoding of afferent baroreceptor activity in the rat. in Anon (ed.), Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2 edn, vol. 17, pp. 1369-1370, Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2), Montreal, Can, 9/20/95.
Schild JH, Clark JW, Andresen M. Pre- and postsynaptic factors influencing the neural encoding of afferent baroreceptor activity in the rat. In Anon, editor, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. 2 ed. Vol. 17. 1995. p. 1369-1370
Schild, J. H. ; Clark, J. W. ; Andresen, Michael. / Pre- and postsynaptic factors influencing the neural encoding of afferent baroreceptor activity in the rat. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings. editor / Anon. Vol. 17 2. ed. 1995. pp. 1369-1370
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