Positive patch-test reactions to iodopropynyl butylcarbamate

retrospective analysis of North American contact dermatitis group data, from 1998 to 2008

Erin M. Warshaw, Dilangani Boralessa Ratnayake, Howard I. Maibach, Denis Sasseville, Donald V. Belsito, Kathryn A. Zug, Joseph F. Fowler, James S. Taylor, C. G Toby Mathias, Anthony F. Fransway, Vincent A. DeLeo, James G. Marks, Frances Storrs, Melanie D. Pratt, Robert L. Rietschel

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Iodopropynyl butylcarbamate (IPBC), a commonly used preservative, is found in industrial and personal care products. Objective: To evaluate prevalence, clinical relevance, occupational relationship, and sources of positive reactions to IPBC in patients in North America. Methods: The North American Contact Dermatitis Group (NACDG) tested IPBC 0.1% and/or 0.5% in petrolatum (pet) between 1998 and 2008. Two patient groups of interest were defined, based on patch-test reactions to IPBC: weak (+) reactors and strong (++ or +++) reactors. Patient characteristics, site(s) of dermatitis, sources of positive reactions, clinical relevance, and occupational relevance to IPBC were tabulated. Results: Of the 25,321 patients tested, there were 226 (0.9%) weak reactors and 67 (0.3%) strong reactors. For IPBC-positive patients, the most frequent sites of dermatitis were scattered generalized distribution, hands, and arms. The majority (> 50%) of currently relevant reactions were to personal care products, and most reactions (> 90%) were not related to occupation. Only four of the strong reactors had definite clinical relevance (positive use-test reaction or positive patch-test reaction to a product containing IPBC). The frequency of positive reactions increased (0.2% vs 1.5%) when the higher concentration of IPBC was utilized, but most (> 64%) were weak reactions, of which some were likely irritant. Conclusions: Allergy to IPBC is relatively uncommon. When clinically relevant, personal care products were the most likely allergen source. Because IPBC is a marginal irritant, caution should be utilized when testing with higher concentrations of IPBC (≥ 0.5% pet) and when interpreting weak (+) reactions. Verification of clinical relevance by use test or repeat patch testing or both is also important.

Original languageEnglish (US)
Pages (from-to)303-310
Number of pages8
JournalDermatitis
Volume21
Issue number6
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Patch Tests
Contact Dermatitis
Petrolatum
Irritants
Dermatitis
3-iodo-2-propynylbutylcarbamate
Public Opinion
North America
Occupations
Allergens
Hypersensitivity
Arm
Hand

ASJC Scopus subject areas

  • Dermatology
  • Immunology and Allergy

Cite this

Warshaw, E. M., Ratnayake, D. B., Maibach, H. I., Sasseville, D., Belsito, D. V., Zug, K. A., ... Rietschel, R. L. (2010). Positive patch-test reactions to iodopropynyl butylcarbamate: retrospective analysis of North American contact dermatitis group data, from 1998 to 2008. Dermatitis, 21(6), 303-310. https://doi.org/10.2310/6620.2010.10053

Positive patch-test reactions to iodopropynyl butylcarbamate : retrospective analysis of North American contact dermatitis group data, from 1998 to 2008. / Warshaw, Erin M.; Ratnayake, Dilangani Boralessa; Maibach, Howard I.; Sasseville, Denis; Belsito, Donald V.; Zug, Kathryn A.; Fowler, Joseph F.; Taylor, James S.; Mathias, C. G Toby; Fransway, Anthony F.; DeLeo, Vincent A.; Marks, James G.; Storrs, Frances; Pratt, Melanie D.; Rietschel, Robert L.

In: Dermatitis, Vol. 21, No. 6, 11.2010, p. 303-310.

Research output: Contribution to journalArticle

Warshaw, EM, Ratnayake, DB, Maibach, HI, Sasseville, D, Belsito, DV, Zug, KA, Fowler, JF, Taylor, JS, Mathias, CGT, Fransway, AF, DeLeo, VA, Marks, JG, Storrs, F, Pratt, MD & Rietschel, RL 2010, 'Positive patch-test reactions to iodopropynyl butylcarbamate: retrospective analysis of North American contact dermatitis group data, from 1998 to 2008', Dermatitis, vol. 21, no. 6, pp. 303-310. https://doi.org/10.2310/6620.2010.10053
Warshaw, Erin M. ; Ratnayake, Dilangani Boralessa ; Maibach, Howard I. ; Sasseville, Denis ; Belsito, Donald V. ; Zug, Kathryn A. ; Fowler, Joseph F. ; Taylor, James S. ; Mathias, C. G Toby ; Fransway, Anthony F. ; DeLeo, Vincent A. ; Marks, James G. ; Storrs, Frances ; Pratt, Melanie D. ; Rietschel, Robert L. / Positive patch-test reactions to iodopropynyl butylcarbamate : retrospective analysis of North American contact dermatitis group data, from 1998 to 2008. In: Dermatitis. 2010 ; Vol. 21, No. 6. pp. 303-310.
@article{2f95f08dfbc14ec4ae6b7fb2dee2b25b,
title = "Positive patch-test reactions to iodopropynyl butylcarbamate: retrospective analysis of North American contact dermatitis group data, from 1998 to 2008",
abstract = "Background: Iodopropynyl butylcarbamate (IPBC), a commonly used preservative, is found in industrial and personal care products. Objective: To evaluate prevalence, clinical relevance, occupational relationship, and sources of positive reactions to IPBC in patients in North America. Methods: The North American Contact Dermatitis Group (NACDG) tested IPBC 0.1{\%} and/or 0.5{\%} in petrolatum (pet) between 1998 and 2008. Two patient groups of interest were defined, based on patch-test reactions to IPBC: weak (+) reactors and strong (++ or +++) reactors. Patient characteristics, site(s) of dermatitis, sources of positive reactions, clinical relevance, and occupational relevance to IPBC were tabulated. Results: Of the 25,321 patients tested, there were 226 (0.9{\%}) weak reactors and 67 (0.3{\%}) strong reactors. For IPBC-positive patients, the most frequent sites of dermatitis were scattered generalized distribution, hands, and arms. The majority (> 50{\%}) of currently relevant reactions were to personal care products, and most reactions (> 90{\%}) were not related to occupation. Only four of the strong reactors had definite clinical relevance (positive use-test reaction or positive patch-test reaction to a product containing IPBC). The frequency of positive reactions increased (0.2{\%} vs 1.5{\%}) when the higher concentration of IPBC was utilized, but most (> 64{\%}) were weak reactions, of which some were likely irritant. Conclusions: Allergy to IPBC is relatively uncommon. When clinically relevant, personal care products were the most likely allergen source. Because IPBC is a marginal irritant, caution should be utilized when testing with higher concentrations of IPBC (≥ 0.5{\%} pet) and when interpreting weak (+) reactions. Verification of clinical relevance by use test or repeat patch testing or both is also important.",
author = "Warshaw, {Erin M.} and Ratnayake, {Dilangani Boralessa} and Maibach, {Howard I.} and Denis Sasseville and Belsito, {Donald V.} and Zug, {Kathryn A.} and Fowler, {Joseph F.} and Taylor, {James S.} and Mathias, {C. G Toby} and Fransway, {Anthony F.} and DeLeo, {Vincent A.} and Marks, {James G.} and Frances Storrs and Pratt, {Melanie D.} and Rietschel, {Robert L.}",
year = "2010",
month = "11",
doi = "10.2310/6620.2010.10053",
language = "English (US)",
volume = "21",
pages = "303--310",
journal = "Dermatitis : contact, atopic, occupational, drug",
issn = "1710-3568",
publisher = "Decker Publishing",
number = "6",

}

TY - JOUR

T1 - Positive patch-test reactions to iodopropynyl butylcarbamate

T2 - retrospective analysis of North American contact dermatitis group data, from 1998 to 2008

AU - Warshaw, Erin M.

AU - Ratnayake, Dilangani Boralessa

AU - Maibach, Howard I.

AU - Sasseville, Denis

AU - Belsito, Donald V.

AU - Zug, Kathryn A.

AU - Fowler, Joseph F.

AU - Taylor, James S.

AU - Mathias, C. G Toby

AU - Fransway, Anthony F.

AU - DeLeo, Vincent A.

AU - Marks, James G.

AU - Storrs, Frances

AU - Pratt, Melanie D.

AU - Rietschel, Robert L.

PY - 2010/11

Y1 - 2010/11

N2 - Background: Iodopropynyl butylcarbamate (IPBC), a commonly used preservative, is found in industrial and personal care products. Objective: To evaluate prevalence, clinical relevance, occupational relationship, and sources of positive reactions to IPBC in patients in North America. Methods: The North American Contact Dermatitis Group (NACDG) tested IPBC 0.1% and/or 0.5% in petrolatum (pet) between 1998 and 2008. Two patient groups of interest were defined, based on patch-test reactions to IPBC: weak (+) reactors and strong (++ or +++) reactors. Patient characteristics, site(s) of dermatitis, sources of positive reactions, clinical relevance, and occupational relevance to IPBC were tabulated. Results: Of the 25,321 patients tested, there were 226 (0.9%) weak reactors and 67 (0.3%) strong reactors. For IPBC-positive patients, the most frequent sites of dermatitis were scattered generalized distribution, hands, and arms. The majority (> 50%) of currently relevant reactions were to personal care products, and most reactions (> 90%) were not related to occupation. Only four of the strong reactors had definite clinical relevance (positive use-test reaction or positive patch-test reaction to a product containing IPBC). The frequency of positive reactions increased (0.2% vs 1.5%) when the higher concentration of IPBC was utilized, but most (> 64%) were weak reactions, of which some were likely irritant. Conclusions: Allergy to IPBC is relatively uncommon. When clinically relevant, personal care products were the most likely allergen source. Because IPBC is a marginal irritant, caution should be utilized when testing with higher concentrations of IPBC (≥ 0.5% pet) and when interpreting weak (+) reactions. Verification of clinical relevance by use test or repeat patch testing or both is also important.

AB - Background: Iodopropynyl butylcarbamate (IPBC), a commonly used preservative, is found in industrial and personal care products. Objective: To evaluate prevalence, clinical relevance, occupational relationship, and sources of positive reactions to IPBC in patients in North America. Methods: The North American Contact Dermatitis Group (NACDG) tested IPBC 0.1% and/or 0.5% in petrolatum (pet) between 1998 and 2008. Two patient groups of interest were defined, based on patch-test reactions to IPBC: weak (+) reactors and strong (++ or +++) reactors. Patient characteristics, site(s) of dermatitis, sources of positive reactions, clinical relevance, and occupational relevance to IPBC were tabulated. Results: Of the 25,321 patients tested, there were 226 (0.9%) weak reactors and 67 (0.3%) strong reactors. For IPBC-positive patients, the most frequent sites of dermatitis were scattered generalized distribution, hands, and arms. The majority (> 50%) of currently relevant reactions were to personal care products, and most reactions (> 90%) were not related to occupation. Only four of the strong reactors had definite clinical relevance (positive use-test reaction or positive patch-test reaction to a product containing IPBC). The frequency of positive reactions increased (0.2% vs 1.5%) when the higher concentration of IPBC was utilized, but most (> 64%) were weak reactions, of which some were likely irritant. Conclusions: Allergy to IPBC is relatively uncommon. When clinically relevant, personal care products were the most likely allergen source. Because IPBC is a marginal irritant, caution should be utilized when testing with higher concentrations of IPBC (≥ 0.5% pet) and when interpreting weak (+) reactions. Verification of clinical relevance by use test or repeat patch testing or both is also important.

UR - http://www.scopus.com/inward/record.url?scp=78650382501&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650382501&partnerID=8YFLogxK

U2 - 10.2310/6620.2010.10053

DO - 10.2310/6620.2010.10053

M3 - Article

VL - 21

SP - 303

EP - 310

JO - Dermatitis : contact, atopic, occupational, drug

JF - Dermatitis : contact, atopic, occupational, drug

SN - 1710-3568

IS - 6

ER -