Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco

Edwin D. Charlebois, David Bangsberg, Nicholas J. Moss, Matthew R. Moore, Andrew R. Moss, Henry F. Chambers, Françoise Perdreau-Remington

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

The study objective was to determine the prevalence and risk factors for nasal colonization with Staphylococcus aureus and methicillin resistance among the urban poor and to compare antibiotic resistance and genetic similarity to concurrently collected clinical isolates of methicillin-resistant S. aureus (MRSA). A population-based community sample of 833 homeless and marginally housed adults were cultured and compared with 363 clinical isolates of MRSA; 22.8% of the urban poor were colonized with S. aureus. Of S. aureus isolates, 12.0% were methicillin resistant. Overall prevalence of MRSA was 2.8%. Significant multivariate risk factors for MRSA were injection drug use (odds ratio [OR], 9.7), prior endocarditis (OR, 4.1), and prior hospitalization within 1 year (OR, 2.4). Resistance to antimicrobials other than β-lactams was uncommon. Only 2 individuals (0.24%) with MRSA had no known risk factors. A total of 22 of 23 community MRSA genotypically matched clinical MRSA isolates, with 15 of 23 isolates identical to MRSA clones endemic among hospitalized patients.

Original languageEnglish (US)
Pages (from-to)425-433
Number of pages9
JournalClinical Infectious Diseases
Volume34
Issue number4
DOIs
StatePublished - Feb 15 2002
Externally publishedYes

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San Francisco
Methicillin-Resistant Staphylococcus aureus
Population
Staphylococcus aureus
Methicillin Resistance
Odds Ratio
Lactams
Microbial Drug Resistance
Endocarditis
Nose
Hospitalization
Clone Cells
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Charlebois, E. D., Bangsberg, D., Moss, N. J., Moore, M. R., Moss, A. R., Chambers, H. F., & Perdreau-Remington, F. (2002). Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. Clinical Infectious Diseases, 34(4), 425-433. https://doi.org/10.1086/338069

Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. / Charlebois, Edwin D.; Bangsberg, David; Moss, Nicholas J.; Moore, Matthew R.; Moss, Andrew R.; Chambers, Henry F.; Perdreau-Remington, Françoise.

In: Clinical Infectious Diseases, Vol. 34, No. 4, 15.02.2002, p. 425-433.

Research output: Contribution to journalArticle

Charlebois, Edwin D. ; Bangsberg, David ; Moss, Nicholas J. ; Moore, Matthew R. ; Moss, Andrew R. ; Chambers, Henry F. ; Perdreau-Remington, Françoise. / Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco. In: Clinical Infectious Diseases. 2002 ; Vol. 34, No. 4. pp. 425-433.
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