TY - JOUR
T1 - Population-based community prevalence of methicillin-resistant Staphylococcus aureus in the urban poor of San Francisco
AU - Charlebois, Edwin D.
AU - Bangsberg, David R.
AU - Moss, Nicholas J.
AU - Moore, Matthew R.
AU - Moss, Andrew R.
AU - Chambers, Henry F.
AU - Perdreau-Remington, Françoise
N1 - Funding Information:
Financial support: Centers for Disease Control and Prevention (Atlanta), California Emerging Infections Program, the University of California, San Francisco AIDS Clinical Research Program, National Institute of Mental Health, Bethesda, Maryland (grant R01-MH54907), and an unrestricted grant from Pharmacia & Upjohn, Peapack, New Jersey. E.D.C. and D.R.B. were supported in part by the Doris Duke Foundation, New York City. H.F.C. was supported in part by the USPHS and NIH/NIAID (grants AI43959 and AI46610).
PY - 2002/2/15
Y1 - 2002/2/15
N2 - The study objective was to determine the prevalence and risk factors for nasal colonization with Staphylococcus aureus and methicillin resistance among the urban poor and to compare antibiotic resistance and genetic similarity to concurrently collected clinical isolates of methicillin-resistant S. aureus (MRSA). A population-based community sample of 833 homeless and marginally housed adults were cultured and compared with 363 clinical isolates of MRSA; 22.8% of the urban poor were colonized with S. aureus. Of S. aureus isolates, 12.0% were methicillin resistant. Overall prevalence of MRSA was 2.8%. Significant multivariate risk factors for MRSA were injection drug use (odds ratio [OR], 9.7), prior endocarditis (OR, 4.1), and prior hospitalization within 1 year (OR, 2.4). Resistance to antimicrobials other than β-lactams was uncommon. Only 2 individuals (0.24%) with MRSA had no known risk factors. A total of 22 of 23 community MRSA genotypically matched clinical MRSA isolates, with 15 of 23 isolates identical to MRSA clones endemic among hospitalized patients.
AB - The study objective was to determine the prevalence and risk factors for nasal colonization with Staphylococcus aureus and methicillin resistance among the urban poor and to compare antibiotic resistance and genetic similarity to concurrently collected clinical isolates of methicillin-resistant S. aureus (MRSA). A population-based community sample of 833 homeless and marginally housed adults were cultured and compared with 363 clinical isolates of MRSA; 22.8% of the urban poor were colonized with S. aureus. Of S. aureus isolates, 12.0% were methicillin resistant. Overall prevalence of MRSA was 2.8%. Significant multivariate risk factors for MRSA were injection drug use (odds ratio [OR], 9.7), prior endocarditis (OR, 4.1), and prior hospitalization within 1 year (OR, 2.4). Resistance to antimicrobials other than β-lactams was uncommon. Only 2 individuals (0.24%) with MRSA had no known risk factors. A total of 22 of 23 community MRSA genotypically matched clinical MRSA isolates, with 15 of 23 isolates identical to MRSA clones endemic among hospitalized patients.
UR - http://www.scopus.com/inward/record.url?scp=0037083040&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037083040&partnerID=8YFLogxK
U2 - 10.1086/338069
DO - 10.1086/338069
M3 - Article
C2 - 11797167
AN - SCOPUS:0037083040
SN - 1058-4838
VL - 34
SP - 425
EP - 433
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 4
ER -