Polydipsia in rhesus monkeys deficient in omega-3 fatty acids

Sydney Reisbick, Martha Neuringer, Romana Hasnain, William E. Connor

    Research output: Contribution to journalArticle

    53 Citations (Scopus)

    Abstract

    Omega-3 fatty acids are a major component of neural membranes. They are essential nutrients for normal biochemical development of the brain and retina and may affect behavior. In our studies of long-term dietary omega-3 fatty acid deficiency, we have found a new effect of this deficiency in rhesus monkeys. Deficient monkeys visited the home cage drinking spout more frequently than controls (Experiment 1), and drank more water over 24 hours (Experiment 3), ahe increase in intake was mirrored by increased combined output of urine + feces over 24 hours (Experiment 3), and was not due to spillage (Experiment 4). The dietary deficiency greatly reduced omega-3 fatty acids in red blood cells but did not affect serum electrolyte levels. The changes in fluid intake and output may be related to direct or indirect effects on central or peripheral control mechanisms for drinking or excretion, which may be mediated by altered composition of neural or other membranes or changes in eicosanoid metabolism.

    Original languageEnglish (US)
    Pages (from-to)315-323
    Number of pages9
    JournalPhysiology and Behavior
    Volume47
    Issue number2
    DOIs
    StatePublished - 1990

    Fingerprint

    Polydipsia
    Omega-3 Fatty Acids
    Macaca mulatta
    lissamine rhodamine B
    Drinking
    Membranes
    Eicosanoids
    Feces
    Electrolytes
    Haplorhini
    Retina
    Erythrocytes
    Urine
    Food
    Water
    Brain
    Serum

    Keywords

    • Drinking
    • Excretion
    • Nutritional deficiency
    • Omega-3 fatty acids
    • Polydipsia
    • Rhesus monkeys
    • Water intake

    ASJC Scopus subject areas

    • Physiology (medical)
    • Behavioral Neuroscience

    Cite this

    Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. / Reisbick, Sydney; Neuringer, Martha; Hasnain, Romana; Connor, William E.

    In: Physiology and Behavior, Vol. 47, No. 2, 1990, p. 315-323.

    Research output: Contribution to journalArticle

    Reisbick, Sydney ; Neuringer, Martha ; Hasnain, Romana ; Connor, William E. / Polydipsia in rhesus monkeys deficient in omega-3 fatty acids. In: Physiology and Behavior. 1990 ; Vol. 47, No. 2. pp. 315-323.
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