Poly-IC preconditioning protects against cerebral and renal ischemia-reperfusion injury

Amy E.B. Packard, Jason C. Hedges, Frances R. Bahjat, Susan L. Stevens, Michael J. Conlin, Andres M. Salazar, Mary P. Stenzel-Poore

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

Preconditioning induces ischemic tolerance, which confers robust protection against ischemic damage. We show marked protection with polyinosinic polycytidylic acid (poly-IC) preconditioning in three models of murine ischemia-reperfusion injury. Poly-IC preconditioning induced protection against ischemia modeled in vitro in brain cortical cells and in vivo in models of brain ischemia and renal ischemia. Further, unlike other Toll-like receptor (TLR) ligands, which generally induce significant inflammatory responses, poly-IC elicits only modest systemic inflammation. Results show that poly-IC is a new powerful prophylactic treatment that offers promise as a clinical therapeutic strategy to minimize damage in patient populations at risk of ischemic injury.

Original languageEnglish (US)
Pages (from-to)242-247
Number of pages6
JournalJournal of Cerebral Blood Flow and Metabolism
Volume32
Issue number2
DOIs
StatePublished - Feb 1 2012

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Keywords

  • cerebrovascular disease
  • focal ischemia
  • inflammation
  • ischemic preconditioning and induced tolerance
  • neuroprotection

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

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