Polarized light for medical diagnostics

Steven Jacques

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Optical imaging can be conducted on both the microscopic scale and the macroscopic scale. Microscopic examination can observe cellular structure and biomarkers, using absorptive and uorescent dyes and phase-sensitive techniques, and observe tissue architecture using optical coherence tomography. Practical clinical optical imaging, however, must still survey large tracts on tissue, on the scale of many millimeters or centimeters. Yet such macroscopic surveillance must remain sensitive to the microscale structure of the tissue in order to achieve meaningful contrast. Toward this surveillance task, several investigative groups are developing label-free imaging based on light scattering. While a pixel in a macroscopic image does not image the microscale, it can characterize the microscale of tissue within that pixel by the absorption, uorescence, and scattering behavior. In order to use label-free scattering as a contrast mechanism, an understanding of the relation between light scattering and tissue microscale structure, from the sub-nm to several µm scale, is being developed.

Original languageEnglish (US)
Title of host publicationBiomedical Photonics Handbook, Second Edition
Subtitle of host publicationBiomedical Diagnostics
PublisherCRC Press
Pages399-413
Number of pages15
ISBN (Electronic)9781420085150
ISBN (Print)9781420085143
DOIs
StatePublished - Jan 1 2014
Externally publishedYes

Fingerprint

Light polarization
polarized light
microbalances
Tissue
Light
Optical Imaging
surveillance
Imaging techniques
Light scattering
Labels
light scattering
Pixels
pixels
Scattering
biomarkers
Optical tomography
Optical Coherence Tomography
Biomarkers
Cellular Structures
scattering

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)
  • Engineering(all)

Cite this

Jacques, S. (2014). Polarized light for medical diagnostics. In Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics (pp. 399-413). CRC Press. https://doi.org/10.1201/b17289

Polarized light for medical diagnostics. / Jacques, Steven.

Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics. CRC Press, 2014. p. 399-413.

Research output: Chapter in Book/Report/Conference proceedingChapter

Jacques, S 2014, Polarized light for medical diagnostics. in Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics. CRC Press, pp. 399-413. https://doi.org/10.1201/b17289
Jacques S. Polarized light for medical diagnostics. In Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics. CRC Press. 2014. p. 399-413 https://doi.org/10.1201/b17289
Jacques, Steven. / Polarized light for medical diagnostics. Biomedical Photonics Handbook, Second Edition: Biomedical Diagnostics. CRC Press, 2014. pp. 399-413
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