Pleasure rather than salience activates human nucleus accumbens and medial prefrontal cortex

Dean Sabatinelli, Margaret M. Bradley, Peter J. Lang, Vincent Costa, Francesco Versace

Research output: Contribution to journalArticle

131 Citations (Scopus)

Abstract

Recent human functional imaging studies have linked the processing of pleasant visual stimuli to activity in mesolimbic reward structures. However, whether the activation is driven specifically by the pleasantness of the stimulus, or by its salience, is unresolved. Here we find in two studies that free viewing of pleasant images of erotic and romantic couples prompts clear, reliable increases in nucleus accumbens (NAc) and medial prefrontal cortex (mPFC) activity, whereas equally arousing (salient) unpleasant images, and neutral pictures, do not. These data suggest that in visual perception, the human NAc and mPFC are specifically reactive to pleasant, rewarding stimuli and are not engaged by unpleasant stimuli, despite high stimulus salience.

Original languageEnglish (US)
Pages (from-to)1374-1379
Number of pages6
JournalJournal of Neurophysiology
Volume98
Issue number3
DOIs
StatePublished - Sep 1 2007
Externally publishedYes

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Pleasure
Nucleus Accumbens
Prefrontal Cortex
Visual Perception
Reward

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

Pleasure rather than salience activates human nucleus accumbens and medial prefrontal cortex. / Sabatinelli, Dean; Bradley, Margaret M.; Lang, Peter J.; Costa, Vincent; Versace, Francesco.

In: Journal of Neurophysiology, Vol. 98, No. 3, 01.09.2007, p. 1374-1379.

Research output: Contribution to journalArticle

Sabatinelli, Dean ; Bradley, Margaret M. ; Lang, Peter J. ; Costa, Vincent ; Versace, Francesco. / Pleasure rather than salience activates human nucleus accumbens and medial prefrontal cortex. In: Journal of Neurophysiology. 2007 ; Vol. 98, No. 3. pp. 1374-1379.
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