Platelets and von Willebrand factor in atherogenesis

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The role of platelet adhesion, activation, and aggregation in acute atherothrombotic events such as myocardial infarction and strokeis wellestablished. Thereis increasing evidence that platelet-endothelial interactions also contribute to early atherosclerotic plaque initiation and growth. Through these interactions, platelet-derived factors can contribute to the proinflammatory and mitogenic status of resident mural cells. Among the many putative mechanisms for platelet-endothelial interactions, increased endothelial-associated von Willebrand factor, particularly in a multimerized form, which interacts with platelet glycoproteins and integrins, is a major factor and represents a therapeutic target in early atherogenesis.

Original languageEnglish (US)
Pages (from-to)1415-1419
Number of pages5
JournalBlood
Volume129
Issue number11
DOIs
StatePublished - Mar 16 2017

Fingerprint

von Willebrand Factor
Platelets
Atherosclerosis
Blood Platelets
Platelet Membrane Glycoproteins
Platelet Activation
Atherosclerotic Plaques
Platelet Aggregation
Integrins
Myocardial Infarction
Adhesion
Agglomeration
Chemical activation
Growth
Therapeutics

ASJC Scopus subject areas

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Platelets and von Willebrand factor in atherogenesis. / Wu, Melinda D.; Atkinson, Tamara (Tami); Lindner, Jonathan.

In: Blood, Vol. 129, No. 11, 16.03.2017, p. 1415-1419.

Research output: Contribution to journalArticle

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