Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery

David E. Cummings, David S. Weigle, R. Scott Frayo, Patricia A. Breen, Marina K. Ma, E. Patchen Dellinger, Jonathan Purnell

Research output: Contribution to journalArticle

1807 Citations (Scopus)

Abstract

Background: Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates in the adaptive response to weight loss, its levels should rise with dieting. Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion. Methods: We determined the 24-hour plasma ghrelin profiles, body composition, insulin levels, leptin levels, and insulin sensitivity in 13 obese subjects before and after a six-month dietary program for weight loss. The 24-hour ghrelin profiles were also determined in 5 subjects who had lost weight after gastric bypass and 10 normal-weight controls; 5 of the 13 obese subjects who participated in the dietary program were matched to the subjects in the gastric bypass group and served as obese controls. Results: Plasma ghrelin levels rose sharply shortly before and fell shortly after every meal. A diet-induced weight loss of 17 percent of initial body weight was associated with a 24 percent increase in the area under the curve for the 24-hour ghrelin profile (P=0.006). In contrast, despite a 36 percent weight loss after gastric bypass, the area under the curve for the ghrelin profile in the gastric-bypass group was 77 percent lower than in normal-weight controls (P

Original languageEnglish (US)
Pages (from-to)1623-1630
Number of pages8
JournalNew England Journal of Medicine
Volume346
Issue number21
DOIs
StatePublished - May 23 2002

Fingerprint

Reducing Diet
Ghrelin
Gastric Bypass
Weight Loss
Weights and Measures
Area Under Curve
Weight Reduction Programs
Appetite
Leptin
Body Composition
Energy Metabolism
Meals
Insulin Resistance
Rodentia
Stomach
Eating
Body Weight
Hormones
Insulin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cummings, D. E., Weigle, D. S., Scott Frayo, R., Breen, P. A., Ma, M. K., Patchen Dellinger, E., & Purnell, J. (2002). Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New England Journal of Medicine, 346(21), 1623-1630. https://doi.org/10.1056/NEJMoa012908

Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. / Cummings, David E.; Weigle, David S.; Scott Frayo, R.; Breen, Patricia A.; Ma, Marina K.; Patchen Dellinger, E.; Purnell, Jonathan.

In: New England Journal of Medicine, Vol. 346, No. 21, 23.05.2002, p. 1623-1630.

Research output: Contribution to journalArticle

Cummings, DE, Weigle, DS, Scott Frayo, R, Breen, PA, Ma, MK, Patchen Dellinger, E & Purnell, J 2002, 'Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery', New England Journal of Medicine, vol. 346, no. 21, pp. 1623-1630. https://doi.org/10.1056/NEJMoa012908
Cummings DE, Weigle DS, Scott Frayo R, Breen PA, Ma MK, Patchen Dellinger E et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. New England Journal of Medicine. 2002 May 23;346(21):1623-1630. https://doi.org/10.1056/NEJMoa012908
Cummings, David E. ; Weigle, David S. ; Scott Frayo, R. ; Breen, Patricia A. ; Ma, Marina K. ; Patchen Dellinger, E. ; Purnell, Jonathan. / Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. In: New England Journal of Medicine. 2002 ; Vol. 346, No. 21. pp. 1623-1630.
@article{ce0ccc0fb88941d8a2c2e755f0aebd83,
title = "Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery",
abstract = "Background: Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates in the adaptive response to weight loss, its levels should rise with dieting. Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion. Methods: We determined the 24-hour plasma ghrelin profiles, body composition, insulin levels, leptin levels, and insulin sensitivity in 13 obese subjects before and after a six-month dietary program for weight loss. The 24-hour ghrelin profiles were also determined in 5 subjects who had lost weight after gastric bypass and 10 normal-weight controls; 5 of the 13 obese subjects who participated in the dietary program were matched to the subjects in the gastric bypass group and served as obese controls. Results: Plasma ghrelin levels rose sharply shortly before and fell shortly after every meal. A diet-induced weight loss of 17 percent of initial body weight was associated with a 24 percent increase in the area under the curve for the 24-hour ghrelin profile (P=0.006). In contrast, despite a 36 percent weight loss after gastric bypass, the area under the curve for the ghrelin profile in the gastric-bypass group was 77 percent lower than in normal-weight controls (P",
author = "Cummings, {David E.} and Weigle, {David S.} and {Scott Frayo}, R. and Breen, {Patricia A.} and Ma, {Marina K.} and {Patchen Dellinger}, E. and Jonathan Purnell",
year = "2002",
month = "5",
day = "23",
doi = "10.1056/NEJMoa012908",
language = "English (US)",
volume = "346",
pages = "1623--1630",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "21",

}

TY - JOUR

T1 - Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery

AU - Cummings, David E.

AU - Weigle, David S.

AU - Scott Frayo, R.

AU - Breen, Patricia A.

AU - Ma, Marina K.

AU - Patchen Dellinger, E.

AU - Purnell, Jonathan

PY - 2002/5/23

Y1 - 2002/5/23

N2 - Background: Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates in the adaptive response to weight loss, its levels should rise with dieting. Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion. Methods: We determined the 24-hour plasma ghrelin profiles, body composition, insulin levels, leptin levels, and insulin sensitivity in 13 obese subjects before and after a six-month dietary program for weight loss. The 24-hour ghrelin profiles were also determined in 5 subjects who had lost weight after gastric bypass and 10 normal-weight controls; 5 of the 13 obese subjects who participated in the dietary program were matched to the subjects in the gastric bypass group and served as obese controls. Results: Plasma ghrelin levels rose sharply shortly before and fell shortly after every meal. A diet-induced weight loss of 17 percent of initial body weight was associated with a 24 percent increase in the area under the curve for the 24-hour ghrelin profile (P=0.006). In contrast, despite a 36 percent weight loss after gastric bypass, the area under the curve for the ghrelin profile in the gastric-bypass group was 77 percent lower than in normal-weight controls (P

AB - Background: Weight loss causes changes in appetite and energy expenditure that promote weight regain. Ghrelin is a hormone that increases food intake in rodents and humans. If circulating ghrelin participates in the adaptive response to weight loss, its levels should rise with dieting. Because ghrelin is produced primarily by the stomach, weight loss after gastric bypass surgery may be accompanied by impaired ghrelin secretion. Methods: We determined the 24-hour plasma ghrelin profiles, body composition, insulin levels, leptin levels, and insulin sensitivity in 13 obese subjects before and after a six-month dietary program for weight loss. The 24-hour ghrelin profiles were also determined in 5 subjects who had lost weight after gastric bypass and 10 normal-weight controls; 5 of the 13 obese subjects who participated in the dietary program were matched to the subjects in the gastric bypass group and served as obese controls. Results: Plasma ghrelin levels rose sharply shortly before and fell shortly after every meal. A diet-induced weight loss of 17 percent of initial body weight was associated with a 24 percent increase in the area under the curve for the 24-hour ghrelin profile (P=0.006). In contrast, despite a 36 percent weight loss after gastric bypass, the area under the curve for the ghrelin profile in the gastric-bypass group was 77 percent lower than in normal-weight controls (P

UR - http://www.scopus.com/inward/record.url?scp=0037162116&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037162116&partnerID=8YFLogxK

U2 - 10.1056/NEJMoa012908

DO - 10.1056/NEJMoa012908

M3 - Article

C2 - 12023994

AN - SCOPUS:0037162116

VL - 346

SP - 1623

EP - 1630

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 21

ER -