Abstract
The feminization frequently observed in men with alcoholic liver disease has not been satisfactorily explained by existing reports. We have measured plasma estrone, prolactin, estrogen-stimulated neuorphysin, and sex steroid-binding globulin concentrations in 50 men with chronic alcoholism and varying degrees of alcoholic liver disease in an effort to further elucidate possible hormonal mechanisms responsible for the observed feminization. Plasma concentrations of each of these parameters were at least two-fold elevated (p {slanted equal to or less-than} 0.01) when compared to values obtained for the same steroid or protein in plasma obtained from normal men. The plasma concentrations of estrone and prolactin in men studied with gynecomastia were significantly greater (p {slanted equal to or less-than} 0.01 and p {slanted equal to or less-than} 0.05, respectively) than were the concentrations of these two hormones in those without this physical sign. Similarly, those men with spider angiomata had significantly greater (p {slanted equal to or less-than} 0.01) plasma estrone levels than did the men without this cutaneous vascular abnormality. These significant hormone elevations may contribute to the pathogenesis of feminization so frequently observed in chronic alcoholic men.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1015-1019 |
| Number of pages | 5 |
| Journal | Metabolism |
| Volume | 24 |
| Issue number | 9 |
| DOIs | |
| State | Published - 1975 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
Cite this
Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men. / Van Thiel, David H.; Gavaler, Judith S.; Lester, Roger; Loriaux, Donald (Lynn); Braunstein, Glenn D.
In: Metabolism, Vol. 24, No. 9, 1975, p. 1015-1019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men
AU - Van Thiel, David H.
AU - Gavaler, Judith S.
AU - Lester, Roger
AU - Loriaux, Donald (Lynn)
AU - Braunstein, Glenn D.
PY - 1975
Y1 - 1975
N2 - The feminization frequently observed in men with alcoholic liver disease has not been satisfactorily explained by existing reports. We have measured plasma estrone, prolactin, estrogen-stimulated neuorphysin, and sex steroid-binding globulin concentrations in 50 men with chronic alcoholism and varying degrees of alcoholic liver disease in an effort to further elucidate possible hormonal mechanisms responsible for the observed feminization. Plasma concentrations of each of these parameters were at least two-fold elevated (p {slanted equal to or less-than} 0.01) when compared to values obtained for the same steroid or protein in plasma obtained from normal men. The plasma concentrations of estrone and prolactin in men studied with gynecomastia were significantly greater (p {slanted equal to or less-than} 0.01 and p {slanted equal to or less-than} 0.05, respectively) than were the concentrations of these two hormones in those without this physical sign. Similarly, those men with spider angiomata had significantly greater (p {slanted equal to or less-than} 0.01) plasma estrone levels than did the men without this cutaneous vascular abnormality. These significant hormone elevations may contribute to the pathogenesis of feminization so frequently observed in chronic alcoholic men.
AB - The feminization frequently observed in men with alcoholic liver disease has not been satisfactorily explained by existing reports. We have measured plasma estrone, prolactin, estrogen-stimulated neuorphysin, and sex steroid-binding globulin concentrations in 50 men with chronic alcoholism and varying degrees of alcoholic liver disease in an effort to further elucidate possible hormonal mechanisms responsible for the observed feminization. Plasma concentrations of each of these parameters were at least two-fold elevated (p {slanted equal to or less-than} 0.01) when compared to values obtained for the same steroid or protein in plasma obtained from normal men. The plasma concentrations of estrone and prolactin in men studied with gynecomastia were significantly greater (p {slanted equal to or less-than} 0.01 and p {slanted equal to or less-than} 0.05, respectively) than were the concentrations of these two hormones in those without this physical sign. Similarly, those men with spider angiomata had significantly greater (p {slanted equal to or less-than} 0.01) plasma estrone levels than did the men without this cutaneous vascular abnormality. These significant hormone elevations may contribute to the pathogenesis of feminization so frequently observed in chronic alcoholic men.
UR - http://www.scopus.com/inward/record.url?scp=0016840255&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016840255&partnerID=8YFLogxK
U2 - 10.1016/0026-0495(75)90094-3
DO - 10.1016/0026-0495(75)90094-3
M3 - Article
C2 - 50551
AN - SCOPUS:0016840255
VL - 24
SP - 1015
EP - 1019
JO - Metabolism: Clinical and Experimental
JF - Metabolism: Clinical and Experimental
SN - 0026-0495
IS - 9
ER -