Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men

David H. Van Thiel, Judith S. Gavaler, Roger Lester, Donald (Lynn) Loriaux, Glenn D. Braunstein

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The feminization frequently observed in men with alcoholic liver disease has not been satisfactorily explained by existing reports. We have measured plasma estrone, prolactin, estrogen-stimulated neuorphysin, and sex steroid-binding globulin concentrations in 50 men with chronic alcoholism and varying degrees of alcoholic liver disease in an effort to further elucidate possible hormonal mechanisms responsible for the observed feminization. Plasma concentrations of each of these parameters were at least two-fold elevated (p {slanted equal to or less-than} 0.01) when compared to values obtained for the same steroid or protein in plasma obtained from normal men. The plasma concentrations of estrone and prolactin in men studied with gynecomastia were significantly greater (p {slanted equal to or less-than} 0.01 and p {slanted equal to or less-than} 0.05, respectively) than were the concentrations of these two hormones in those without this physical sign. Similarly, those men with spider angiomata had significantly greater (p {slanted equal to or less-than} 0.01) plasma estrone levels than did the men without this cutaneous vascular abnormality. These significant hormone elevations may contribute to the pathogenesis of feminization so frequently observed in chronic alcoholic men.

Original languageEnglish (US)
Pages (from-to)1015-1019
Number of pages5
JournalMetabolism
Volume24
Issue number9
DOIs
StatePublished - 1975
Externally publishedYes

Fingerprint

Neurophysins
Estrone
Globulins
Alcoholics
Prolactin
Steroids
Feminization
Alcoholic Liver Diseases
Skin Abnormalities
Hormones
Gynecomastia
Spiders
Hemangioma
Alcoholism
Blood Vessels
Blood Proteins
Estrogens

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men. / Van Thiel, David H.; Gavaler, Judith S.; Lester, Roger; Loriaux, Donald (Lynn); Braunstein, Glenn D.

In: Metabolism, Vol. 24, No. 9, 1975, p. 1015-1019.

Research output: Contribution to journalArticle

Van Thiel, David H. ; Gavaler, Judith S. ; Lester, Roger ; Loriaux, Donald (Lynn) ; Braunstein, Glenn D. / Plasma estrone, prolactin, neurophysin, and sex steroid-binding globulin in chronic alcoholic men. In: Metabolism. 1975 ; Vol. 24, No. 9. pp. 1015-1019.
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