Plants with neurotoxic potential in undernourished subjects

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

The consumption by humans of plants with potential to induce neurological disorders is widespread, but overt disease surfaces only when the subject's toxic threshold is exceeded. Excessive intake arising from food dependency in the setting of hunger, chronic undernutrition, vitamin deficiency, inadequate detoxication, or other individual susceptibility, can trigger acute encephalopathy (lychee, ackee fruits), sub-acute spastic paraparesis (grasspea, cassava root/leaves) or ataxic neuropathy (cassava root flour). While these disorders are very rarely encountered in high-income countries, they are not only common among impoverished populations but also often occur as outbreaks that impact a significant proportion of an affected community. Unfamiliarity with the adverse effects of plant toxins has sometimes led to the mistaken attribution of nutritional neurotoxic disease to a neurotropic viral or synthetic pesticidal etiology. The combination of human population growth, food and water insecurity, poverty and, with climate change, increased dependency on environmentally tolerant plants with neurotoxic potential, predictably may result in an increased prevalence of nutritional neurotoxic disorders, especially in certain parts of Africa and Asia.

Original languageEnglish (US)
JournalRevue Neurologique
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Manihot
Blighia
Litchi
Neurotoxicity Syndromes
Spastic Paraparesis
Nutrition Disorders
Avitaminosis
Hunger
Food Supply
Climate Change
Poisons
Population Growth
Brain Diseases
Flour
Poverty
Nervous System Diseases
Malnutrition
Disease Outbreaks
Fruit
Eating

Keywords

  • Ackee
  • Cassava
  • Global public health
  • Grasspea
  • Lychee
  • Malnutrition
  • Tropical neurology

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Plants with neurotoxic potential in undernourished subjects. / Palmer, V. S.; Tshala-Katumbay, D. D.; Spencer, P. S.

In: Revue Neurologique, 01.01.2019.

Research output: Contribution to journalReview article

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