Placental transfer of dexamethasone in near-term sheep

Debra Anderson, M. K. Stock, J. H G Rankin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The placental transfer of 3H-dexamethasone was studied in six near-term sheep. The placental clearance of 3H-dexamethasone was 18.8+-3.5 ml/min per kg of fetal weight. The clearance of dexamethasone by the fetal tissues was 9.3+-2.5 ml/min per kg and the degree of diffusion limitation to the placental transfer of dexamethasone was 78+-4%. The placental transfer of dexamethasone is therefore limited primarily by the nature of the placental barrier.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalJournal of Developmental Physiology
Volume1
Issue number6
StatePublished - 1979
Externally publishedYes

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Dexamethasone
Sheep
Fetal Weight
Fetus

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Cite this

Anderson, D., Stock, M. K., & Rankin, J. H. G. (1979). Placental transfer of dexamethasone in near-term sheep. Journal of Developmental Physiology, 1(6), 431-436.

Placental transfer of dexamethasone in near-term sheep. / Anderson, Debra; Stock, M. K.; Rankin, J. H G.

In: Journal of Developmental Physiology, Vol. 1, No. 6, 1979, p. 431-436.

Research output: Contribution to journalArticle

Anderson, D, Stock, MK & Rankin, JHG 1979, 'Placental transfer of dexamethasone in near-term sheep', Journal of Developmental Physiology, vol. 1, no. 6, pp. 431-436.
Anderson, Debra ; Stock, M. K. ; Rankin, J. H G. / Placental transfer of dexamethasone in near-term sheep. In: Journal of Developmental Physiology. 1979 ; Vol. 1, No. 6. pp. 431-436.
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