Placental transfer of dexamethasone in near-term sheep

D. F. Anderson, M. K. Stock, J. H.G. Rankin

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The placental transfer of 3H-dexamethasone was studied in six near-term sheep. The placental clearance of 3H-dexamethasone was 18.8+-3.5 ml/min per kg of fetal weight. The clearance of dexamethasone by the fetal tissues was 9.3+-2.5 ml/min per kg and the degree of diffusion limitation to the placental transfer of dexamethasone was 78+-4%. The placental transfer of dexamethasone is therefore limited primarily by the nature of the placental barrier.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalJournal of Developmental Physiology
Volume1
Issue number6
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology

Fingerprint Dive into the research topics of 'Placental transfer of dexamethasone in near-term sheep'. Together they form a unique fingerprint.

  • Cite this

    Anderson, D. F., Stock, M. K., & Rankin, J. H. G. (1979). Placental transfer of dexamethasone in near-term sheep. Journal of Developmental Physiology, 1(6), 431-436.