The placental transfer of 3H-dexamethasone was studied in six near-term sheep. The placental clearance of 3H-dexamethasone was 18.8+-3.5 ml/min per kg of fetal weight. The clearance of dexamethasone by the fetal tissues was 9.3+-2.5 ml/min per kg and the degree of diffusion limitation to the placental transfer of dexamethasone was 78+-4%. The placental transfer of dexamethasone is therefore limited primarily by the nature of the placental barrier.
|Original language||English (US)|
|Number of pages||6|
|Journal||Journal of Developmental Physiology|
|State||Published - Dec 1 1979|
ASJC Scopus subject areas
- Developmental Biology