Placental transfer of dexamethasone in near-term sheep

D. F. Anderson, M. K. Stock, J. H.G. Rankin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


The placental transfer of 3H-dexamethasone was studied in six near-term sheep. The placental clearance of 3H-dexamethasone was 18.8+-3.5 ml/min per kg of fetal weight. The clearance of dexamethasone by the fetal tissues was 9.3+-2.5 ml/min per kg and the degree of diffusion limitation to the placental transfer of dexamethasone was 78+-4%. The placental transfer of dexamethasone is therefore limited primarily by the nature of the placental barrier.

Original languageEnglish (US)
Pages (from-to)431-436
Number of pages6
JournalJournal of Developmental Physiology
Issue number6
StatePublished - Dec 1 1979
Externally publishedYes

ASJC Scopus subject areas

  • Developmental Biology
  • Physiology


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