Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension

Tiina Erkinaro, Tomi Kavasmaa, Laura Ylikauma, Kaarin Mäkikallio, Mervi Haapsamo, Ganesh Acharya, Pasi Ohtonen, Seppo Alahuhta, Juha Rasanen

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance. Also, we examined fetal and placental hemodynamic responses to acute hypoxemia after antihypertensive medication. Norepinephrine increased maternal heart rate (HR), mean arterial pressure (MAP) and uterine vascular resistance (RUtA), and decreased uterine volume blood flow (QUtA). Both labetalol and pindolol decreased maternal HR, MAP, and RUtA, but did not restore QUtA. Fetal MAP was unaffected while fetal HR and placental volume blood flow (QUA) decreased and placental vascular resistance increased. During hypoxemia, which was induced by decreasing maternal inspiratory oxygen fraction, all these parameters remained unchanged in the labetalol group while fetal HR increased and QUA further decreased in the pindolol group. We conclude that labetalol and pindolol may compromise uterine and placental hemodynamics. Hypoxemic stress provokes divergent hemodynamic responses in fetuses exposed to these differently acting adrenoceptor antagonists.

Original languageEnglish (US)
Pages (from-to)749-757
Number of pages9
JournalReproductive Sciences
Volume16
Issue number8
DOIs
StatePublished - Aug 2009
Externally publishedYes

Fingerprint

Labetalol
Pindolol
Vascular Resistance
Sheep
Hemodynamics
Mothers
Hypertension
Arterial Pressure
Fetal Heart Rate
Blood Volume
Norepinephrine
Heart Rate
Adrenergic Receptors
Antihypertensive Agents
Fetus
Oxygen
Hypoxia

Keywords

  • Fetus.
  • Hypoxemia
  • Labetalol
  • Pindolol
  • Placental circulation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. / Erkinaro, Tiina; Kavasmaa, Tomi; Ylikauma, Laura; Mäkikallio, Kaarin; Haapsamo, Mervi; Acharya, Ganesh; Ohtonen, Pasi; Alahuhta, Seppo; Rasanen, Juha.

In: Reproductive Sciences, Vol. 16, No. 8, 08.2009, p. 749-757.

Research output: Contribution to journalArticle

Erkinaro, T, Kavasmaa, T, Ylikauma, L, Mäkikallio, K, Haapsamo, M, Acharya, G, Ohtonen, P, Alahuhta, S & Rasanen, J 2009, 'Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension', Reproductive Sciences, vol. 16, no. 8, pp. 749-757. https://doi.org/10.1177/1933719109335068
Erkinaro, Tiina ; Kavasmaa, Tomi ; Ylikauma, Laura ; Mäkikallio, Kaarin ; Haapsamo, Mervi ; Acharya, Ganesh ; Ohtonen, Pasi ; Alahuhta, Seppo ; Rasanen, Juha. / Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. In: Reproductive Sciences. 2009 ; Vol. 16, No. 8. pp. 749-757.
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