TY - JOUR
T1 - Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension
AU - Erkinaro, Tiina
AU - Kavasmaa, Tomi
AU - Ylikauma, Laura
AU - Mäkikallio, Kaarin
AU - Haapsamo, Mervi
AU - Acharya, Ganesh
AU - Ohtonen, Pasi
AU - Alahuhta, Seppo
AU - Räsänen, Juha
PY - 2009/8
Y1 - 2009/8
N2 - We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance. Also, we examined fetal and placental hemodynamic responses to acute hypoxemia after antihypertensive medication. Norepinephrine increased maternal heart rate (HR), mean arterial pressure (MAP) and uterine vascular resistance (RUtA), and decreased uterine volume blood flow (QUtA). Both labetalol and pindolol decreased maternal HR, MAP, and RUtA, but did not restore QUtA. Fetal MAP was unaffected while fetal HR and placental volume blood flow (QUA) decreased and placental vascular resistance increased. During hypoxemia, which was induced by decreasing maternal inspiratory oxygen fraction, all these parameters remained unchanged in the labetalol group while fetal HR increased and QUA further decreased in the pindolol group. We conclude that labetalol and pindolol may compromise uterine and placental hemodynamics. Hypoxemic stress provokes divergent hemodynamic responses in fetuses exposed to these differently acting adrenoceptor antagonists.
AB - We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance. Also, we examined fetal and placental hemodynamic responses to acute hypoxemia after antihypertensive medication. Norepinephrine increased maternal heart rate (HR), mean arterial pressure (MAP) and uterine vascular resistance (RUtA), and decreased uterine volume blood flow (QUtA). Both labetalol and pindolol decreased maternal HR, MAP, and RUtA, but did not restore QUtA. Fetal MAP was unaffected while fetal HR and placental volume blood flow (QUA) decreased and placental vascular resistance increased. During hypoxemia, which was induced by decreasing maternal inspiratory oxygen fraction, all these parameters remained unchanged in the labetalol group while fetal HR increased and QUA further decreased in the pindolol group. We conclude that labetalol and pindolol may compromise uterine and placental hemodynamics. Hypoxemic stress provokes divergent hemodynamic responses in fetuses exposed to these differently acting adrenoceptor antagonists.
KW - Fetus.
KW - Hypoxemia
KW - Labetalol
KW - Pindolol
KW - Placental circulation
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U2 - 10.1177/1933719109335068
DO - 10.1177/1933719109335068
M3 - Article
C2 - 19380903
AN - SCOPUS:67650462850
SN - 1933-7191
VL - 16
SP - 749
EP - 757
JO - Reproductive Sciences
JF - Reproductive Sciences
IS - 8
ER -