Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension

Tiina Erkinaro, Tomi Kavasmaa, Laura Ylikauma, Kaarin Mäkikallio, Mervi Haapsamo, Ganesh Acharya, Pasi Ohtonen, Seppo Alahuhta, Juha Räsänen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

We investigated the effects of labetalol and pindolol on uterine, placental, and fetal hemodynamics following norepinephrine-induced maternal hypertension in a sheep model of increased placental vascular resistance. Also, we examined fetal and placental hemodynamic responses to acute hypoxemia after antihypertensive medication. Norepinephrine increased maternal heart rate (HR), mean arterial pressure (MAP) and uterine vascular resistance (RUtA), and decreased uterine volume blood flow (QUtA). Both labetalol and pindolol decreased maternal HR, MAP, and RUtA, but did not restore QUtA. Fetal MAP was unaffected while fetal HR and placental volume blood flow (QUA) decreased and placental vascular resistance increased. During hypoxemia, which was induced by decreasing maternal inspiratory oxygen fraction, all these parameters remained unchanged in the labetalol group while fetal HR increased and QUA further decreased in the pindolol group. We conclude that labetalol and pindolol may compromise uterine and placental hemodynamics. Hypoxemic stress provokes divergent hemodynamic responses in fetuses exposed to these differently acting adrenoceptor antagonists.

Original languageEnglish (US)
Pages (from-to)749-757
Number of pages9
JournalReproductive Sciences
Volume16
Issue number8
DOIs
StatePublished - Aug 1 2009

Keywords

  • Fetus.
  • Hypoxemia
  • Labetalol
  • Pindolol
  • Placental circulation

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Erkinaro, T., Kavasmaa, T., Ylikauma, L., Mäkikallio, K., Haapsamo, M., Acharya, G., Ohtonen, P., Alahuhta, S., & Räsänen, J. (2009). Placental and fetal hemodynamics after labetalol or pindolol in a sheep model of increased placental vascular resistance and maternal hypertension. Reproductive Sciences, 16(8), 749-757. https://doi.org/10.1177/1933719109335068