Pigment Cells of the Eyes in People with Vitiligo

Aaron B. Lerner, James J. Nordlund, Daniel Albert

Research output: Contribution to journalLetter

19 Citations (Scopus)

Abstract

To the Editor: White patches of skin and gray hair occur in people with vitiligo because the pigment cells, melanocytes, are destroyed in skin and hair follicles. A combination of immunologic and cytotoxic mechanisms produces this loss of melanocytes. The prevalence of vitiligo is high in patients with disorders of autoimmunity such as hyperthyroidism, thyroiditis, adrenal insufficiency and pernicious anemia. In addition, patients with melanomas who have strong immunity against malignant melanocytes frequently have vitiligo. One fascinating aspect about the subject is that no matter how extensive the pigment loss and how great the duration of loss, the color. . .

Original languageEnglish (US)
Number of pages1
JournalNew England Journal of Medicine
Volume296
Issue number4
DOIs
StatePublished - Jan 27 1977
Externally publishedYes

Fingerprint

Vitiligo
Melanocytes
Pernicious Anemia
Thyroiditis
Adrenal Insufficiency
Skin
Hair Follicle
Hyperthyroidism
Autoimmunity
Hair
Immunity
Melanoma
Color

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Pigment Cells of the Eyes in People with Vitiligo. / Lerner, Aaron B.; Nordlund, James J.; Albert, Daniel.

In: New England Journal of Medicine, Vol. 296, No. 4, 27.01.1977.

Research output: Contribution to journalLetter

Lerner, Aaron B. ; Nordlund, James J. ; Albert, Daniel. / Pigment Cells of the Eyes in People with Vitiligo. In: New England Journal of Medicine. 1977 ; Vol. 296, No. 4.
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AB - To the Editor: White patches of skin and gray hair occur in people with vitiligo because the pigment cells, melanocytes, are destroyed in skin and hair follicles. A combination of immunologic and cytotoxic mechanisms produces this loss of melanocytes. The prevalence of vitiligo is high in patients with disorders of autoimmunity such as hyperthyroidism, thyroiditis, adrenal insufficiency and pernicious anemia. In addition, patients with melanomas who have strong immunity against malignant melanocytes frequently have vitiligo. One fascinating aspect about the subject is that no matter how extensive the pigment loss and how great the duration of loss, the color. . .

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