Piezos thrive under pressure: Mechanically activated ion channels in health and disease

Swetha E. Murthy, Adrienne E. Dubin, Ardem Patapoutian

Research output: Contribution to journalArticlepeer-review

115 Scopus citations

Abstract

Cellular mechanotransduction, the process of translating mechanical forces into biological signals, is crucial for a wide range of physiological processes. A role for ion channels in sensing mechanical forces has been proposed for decades, but their identity in mammals remained largely elusive until the discovery of Piezos. Recent research on Piezos has underscored their importance in somatosensation (touch perception, proprioception and pulmonary respiration), red blood cell volume regulation, vascular physiology and various human genetic disorders.

Original languageEnglish (US)
Pages (from-to)771-783
Number of pages13
JournalNature Reviews Molecular Cell Biology
Volume18
Issue number12
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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