Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons

Tally M. Largent-Milnes, Deborah M. Hegarty, Sue Aicher, Michael Andresen

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Trigeminal sensory afferent fibers terminating in nucleus caudalis (Vc) relay sensory information from craniofacial regions to the brain and are known to express transient receptor potential (TRP) ion channels. TRP channels are activated by H+, thermal, and chemical stimuli. The present study investigated the relationships among the spontaneous release of glutamate, temperature, and TRPV1 localization at synapses in the Vc. Spontaneous excitatory postsynaptic currents (sEPSCs) were recorded from Vc neurons (n = 151) in horizontal brain-stem slices obtained from Sprague-Dawley rats. Neurons had basal sEPSC rates that fell into two distinct frequency categories: High (≥10 Hz) or Low (

Original languageEnglish (US)
Pages (from-to)2222-2231
Number of pages10
JournalJournal of Neurophysiology
Volume111
Issue number11
DOIs
StatePublished - Jun 1 2014

Fingerprint

Transient Receptor Potential Channels
Posterior Horn Cells
Excitatory Postsynaptic Potentials
Glutamic Acid
Neurons
Temperature
Ion Channels
Synapses
Brain Stem
Sprague Dawley Rats
Hot Temperature
Brain

Keywords

  • Electrophysiology
  • Spontaneous release
  • Temperature
  • Trigeminal nucleus caudalis
  • TRPV1

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)
  • Medicine(all)

Cite this

Physiological temperatures drive glutamate release onto trigeminal superficial dorsal horn neurons. / Largent-Milnes, Tally M.; Hegarty, Deborah M.; Aicher, Sue; Andresen, Michael.

In: Journal of Neurophysiology, Vol. 111, No. 11, 01.06.2014, p. 2222-2231.

Research output: Contribution to journalArticle

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