Phosphorylated α-synuclein in Parkinson's disease

Yu Wang, Min Shi, Kathryn (Kathy) Chung, Cyrus P. Zabetian, James B. Leverenz, Daniela Berg, Karin Srulijes, John Q. Trojanowski, Virginia M Y Lee, Andrew D. Siderowf, Howard Hurtig, Irene Litvan, Mya C. Schiess, Elaine R. Peskind, Masami Masuda, Masato Hasegawa, Xiangmin Lin, Catherine Pan, Douglas Galasko, David S. GoldsteinPoul Henning Jensen, Hui Yang, Kevin C. Cain, Jing Zhang

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Abstract

Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total a-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.

Original languageEnglish (US)
JournalScience Translational Medicine
Volume4
Issue number121
DOIs
StatePublished - Feb 15 2012

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Synucleins
Parkinson Disease
Cerebrospinal Fluid
Progressive Supranuclear Palsy
Multiple System Atrophy
Parkinsonian Disorders
Disease Progression
Mass Spectrometry

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Wang, Y., Shi, M., Chung, K. K., Zabetian, C. P., Leverenz, J. B., Berg, D., ... Zhang, J. (2012). Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine, 4(121). https://doi.org/10.1126/scitranslmed.3002566

Phosphorylated α-synuclein in Parkinson's disease. / Wang, Yu; Shi, Min; Chung, Kathryn (Kathy); Zabetian, Cyrus P.; Leverenz, James B.; Berg, Daniela; Srulijes, Karin; Trojanowski, John Q.; Lee, Virginia M Y; Siderowf, Andrew D.; Hurtig, Howard; Litvan, Irene; Schiess, Mya C.; Peskind, Elaine R.; Masuda, Masami; Hasegawa, Masato; Lin, Xiangmin; Pan, Catherine; Galasko, Douglas; Goldstein, David S.; Jensen, Poul Henning; Yang, Hui; Cain, Kevin C.; Zhang, Jing.

In: Science Translational Medicine, Vol. 4, No. 121, 15.02.2012.

Research output: Contribution to journalArticle

Wang, Y, Shi, M, Chung, KK, Zabetian, CP, Leverenz, JB, Berg, D, Srulijes, K, Trojanowski, JQ, Lee, VMY, Siderowf, AD, Hurtig, H, Litvan, I, Schiess, MC, Peskind, ER, Masuda, M, Hasegawa, M, Lin, X, Pan, C, Galasko, D, Goldstein, DS, Jensen, PH, Yang, H, Cain, KC & Zhang, J 2012, 'Phosphorylated α-synuclein in Parkinson's disease', Science Translational Medicine, vol. 4, no. 121. https://doi.org/10.1126/scitranslmed.3002566
Wang, Yu ; Shi, Min ; Chung, Kathryn (Kathy) ; Zabetian, Cyrus P. ; Leverenz, James B. ; Berg, Daniela ; Srulijes, Karin ; Trojanowski, John Q. ; Lee, Virginia M Y ; Siderowf, Andrew D. ; Hurtig, Howard ; Litvan, Irene ; Schiess, Mya C. ; Peskind, Elaine R. ; Masuda, Masami ; Hasegawa, Masato ; Lin, Xiangmin ; Pan, Catherine ; Galasko, Douglas ; Goldstein, David S. ; Jensen, Poul Henning ; Yang, Hui ; Cain, Kevin C. ; Zhang, Jing. / Phosphorylated α-synuclein in Parkinson's disease. In: Science Translational Medicine. 2012 ; Vol. 4, No. 121.
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