Phosphoinositides and vesicular membrane traffic

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Phosphoinositide lipids were initially discovered as precursors for specific second messengers involved in signal transduction, but have now taken the center stage in controlling many essential processes at virtually every cellular membrane. In particular, phosphoinositides play a critical role in regulating membrane dynamics and vesicular transport. The unique distribution of certain phosphoinositides at specific intracellular membranes makes these molecules uniquely suited to direct organelle-specific trafficking reactions. In this regulatory role, phosphoinositides cooperate specifically with small GTPases from the Arf and Rab families. This review will summarize recent progress in the study of phosphoinositides in membrane trafficking and organellar organization and highlight the particular relevance of these signaling pathways in disease. This article is part of a Special Issue entitled Lipids and Vesicular Transport.

Original languageEnglish (US)
Pages (from-to)1104-1113
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1821
Issue number8
DOIs
StatePublished - Aug 2012

Fingerprint

Phosphatidylinositols
Membranes
Lipids
Intracellular Membranes
Monomeric GTP-Binding Proteins
Second Messenger Systems
Organelles
Signal Transduction

Keywords

  • Endocytosis
  • Golgi
  • Lipid kinase
  • Lipid phosphatase
  • Membrane traffic
  • Phosphoinositide

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Phosphoinositides and vesicular membrane traffic. / Mayinger, Peter.

In: Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Vol. 1821, No. 8, 08.2012, p. 1104-1113.

Research output: Contribution to journalArticle

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