Phosphoinositides and vesicular membrane traffic

Research output: Contribution to journalReview article

67 Scopus citations

Abstract

Phosphoinositide lipids were initially discovered as precursors for specific second messengers involved in signal transduction, but have now taken the center stage in controlling many essential processes at virtually every cellular membrane. In particular, phosphoinositides play a critical role in regulating membrane dynamics and vesicular transport. The unique distribution of certain phosphoinositides at specific intracellular membranes makes these molecules uniquely suited to direct organelle-specific trafficking reactions. In this regulatory role, phosphoinositides cooperate specifically with small GTPases from the Arf and Rab families. This review will summarize recent progress in the study of phosphoinositides in membrane trafficking and organellar organization and highlight the particular relevance of these signaling pathways in disease. This article is part of a Special Issue entitled Lipids and Vesicular Transport.

Original languageEnglish (US)
Pages (from-to)1104-1113
Number of pages10
JournalBiochimica et Biophysica Acta - Molecular and Cell Biology of Lipids
Volume1821
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • Endocytosis
  • Golgi
  • Lipid kinase
  • Lipid phosphatase
  • Membrane traffic
  • Phosphoinositide

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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