TY - JOUR
T1 - Phenotypic overlap between core diagnostic features and emotional/behavioral problems in preschool children with autism spectrum disorder
AU - Georgiades, Stelios
AU - Szatmari, Peter
AU - Duku, Eric
AU - Zwaigenbaum, Lonnie
AU - Bryson, Susan
AU - Roberts, Wendy
AU - Fombonne, Eric
AU - Mirenda, Pat
AU - Smith, Isabel
AU - Vaillancourt, Tracy
AU - Volden, Joanne
AU - Waddell, Charlotte
AU - Thompson, Ann
N1 - Funding Information:
Acknowledgments This study was supported by the Canadian Institutes of Health Research, Autism Speaks, the Government of British Columbia, the Alberta Heritage Foundation for Medical Research, and the Sinneave Family Foundation. The authors thank all the families who participated in the Pathways in ASD study. The authors also acknowledge the members of the Pathways in ASD Study Team. These members had equal contribution to the study and are listed here alphabetically: Liliana Abruzzese, Megan Alexander, Susan Bauld, Terry Bennett, Ainsley Boudreau, Colin Andrew Campbell, Mike Chalupka, Lorna Colli, Melanie Couture, Bev DaSilva, Vikram Dua, Miriam Elfert, Lara El-Khatib, Lindsay Fleming, Kristin Fossum, Nancy Garon, Shareen Holly, Stephanie Jull, Karen Kalynchuk, Kathryne MacLeod, Preetinder Narang, Juli-anne Noseworthy, Irene O’Connor, Kaori Ohashi, Sarah Peacock, Teri Phillips, Sara Quirke, Katie Rinald, Jennifer Saracino, Cathryn Schroeder, Cody Shepherd, Rebecca Simon, Mandy Steiman, Richard Stock, Benjamin Taylor, Lee Tidmarsh, Larry Tuff, Kathryn Vai-llancourt, Stephen Wellington, Isabelle Yun, and Li Hong Zhong.
PY - 2011/10
Y1 - 2011/10
N2 - This study examined the phenotypic overlap between core diagnostic features and emotional/behavioral problems in a sample of 335 preschool children with autism spectrum disorder (ASD). Results from principal component analysis (2 components; 49.70% variance explained) suggested substantial phenotypic overlap between core diagnostic features and emotional/behavioral problems. Component I, Emotional Behavioral Repetitive Problems, was independent of the children's intellectual, adaptive functioning, and structural language abilities. Component II, Social Communication Deficits, was negatively related to the children's intellectual, adaptive functioning, and structural language abilities. Both components were positively related to parental stress. This exploratory study contributes to our understanding of the ASD phenotype and provides further support for including emotional/behavioral problems as part of the clinical characterization of children with ASD.
AB - This study examined the phenotypic overlap between core diagnostic features and emotional/behavioral problems in a sample of 335 preschool children with autism spectrum disorder (ASD). Results from principal component analysis (2 components; 49.70% variance explained) suggested substantial phenotypic overlap between core diagnostic features and emotional/behavioral problems. Component I, Emotional Behavioral Repetitive Problems, was independent of the children's intellectual, adaptive functioning, and structural language abilities. Component II, Social Communication Deficits, was negatively related to the children's intellectual, adaptive functioning, and structural language abilities. Both components were positively related to parental stress. This exploratory study contributes to our understanding of the ASD phenotype and provides further support for including emotional/behavioral problems as part of the clinical characterization of children with ASD.
KW - Autism spectrum disorder
KW - Comorbidity
KW - Emotional/behavioral problems
KW - Phenotype
KW - Principal component analysis
UR - http://www.scopus.com/inward/record.url?scp=82755187450&partnerID=8YFLogxK
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U2 - 10.1007/s10803-010-1158-9
DO - 10.1007/s10803-010-1158-9
M3 - Article
C2 - 21161575
AN - SCOPUS:82755187450
SN - 0162-3257
VL - 41
SP - 1321
EP - 1329
JO - Journal of autism and developmental disorders
JF - Journal of autism and developmental disorders
IS - 10
ER -