Phase-resolved acoustic radiation force optical coherence elastography

Wenjuan Qi, Ruimin Chen, Lidek Chou, Gangjun Liu, Jun Zhang, Qifa Zhou, Zhongping Chen

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.

Original languageEnglish (US)
Article number110505
JournalJournal of Biomedical Optics
Volume17
Issue number11
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

sound waves
Acoustics
Tissue
Radiation
elastic properties
compression tests
Optical tomography
square waves
pathology
Pathology
arteries
excitation
Elasticity
modulus of elasticity
tomography
Elastic moduli
mechanical properties
vibration
Mechanical properties

Keywords

  • acoustic radiation force
  • atherosclerosis
  • elastography
  • mechanical properties
  • optical coherence tomography
  • Young's modulus

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Qi, W., Chen, R., Chou, L., Liu, G., Zhang, J., Zhou, Q., & Chen, Z. (2012). Phase-resolved acoustic radiation force optical coherence elastography. Journal of Biomedical Optics, 17(11), [110505]. https://doi.org/10.1117/1.JBO.17.11.110505

Phase-resolved acoustic radiation force optical coherence elastography. / Qi, Wenjuan; Chen, Ruimin; Chou, Lidek; Liu, Gangjun; Zhang, Jun; Zhou, Qifa; Chen, Zhongping.

In: Journal of Biomedical Optics, Vol. 17, No. 11, 110505, 11.2012.

Research output: Contribution to journalArticle

Qi, W, Chen, R, Chou, L, Liu, G, Zhang, J, Zhou, Q & Chen, Z 2012, 'Phase-resolved acoustic radiation force optical coherence elastography', Journal of Biomedical Optics, vol. 17, no. 11, 110505. https://doi.org/10.1117/1.JBO.17.11.110505
Qi, Wenjuan ; Chen, Ruimin ; Chou, Lidek ; Liu, Gangjun ; Zhang, Jun ; Zhou, Qifa ; Chen, Zhongping. / Phase-resolved acoustic radiation force optical coherence elastography. In: Journal of Biomedical Optics. 2012 ; Vol. 17, No. 11.
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