TY - JOUR
T1 - Phase-resolved acoustic radiation force optical coherence elastography
AU - Qi, Wenjuan
AU - Chen, Ruimin
AU - Chou, Lidek
AU - Liu, Gangjun
AU - Zhang, Jun
AU - Zhou, Qifa
AU - Chen, Zhongping
N1 - Funding Information:
The authors thank Claire Robertson for the phantom compression test, Jiawen Li for preparing the tissue, and the individuals who donated their bodies and tissues for the advancement of education and research. This work was supported by the National Institutes of Health (EB-10090, EY-021519, HL-105215, HL-103764, and EB-015890), the Air Force Office of Scientific Research (FA9550-04-0101), and the Arnold and Mabel Beckman Foundation. Dr. Chen has a financial interest in OCT Medical Imaging Inc., which, however, did not support this work.
PY - 2012/11
Y1 - 2012/11
N2 - Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.
AB - Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.
KW - Young's modulus
KW - acoustic radiation force
KW - atherosclerosis
KW - elastography
KW - mechanical properties
KW - optical coherence tomography
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U2 - 10.1117/1.JBO.17.11.110505
DO - 10.1117/1.JBO.17.11.110505
M3 - Article
C2 - 23123971
AN - SCOPUS:84870578792
SN - 1083-3668
VL - 17
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 11
M1 - 110505
ER -