Phase-resolved acoustic radiation force optical coherence elastography

Wenjuan Qi, Ruimin Chen, Lidek Chou, Gangjun Liu, Jun Zhang, Qifa Zhou, Zhongping Chen

Research output: Contribution to journalArticle

67 Scopus citations

Abstract

Many diseases involve changes in the biomechanical properties of tissue, and there is a close correlation between tissue elasticity and pathology. We report on the development of a phase-resolved acoustic radiation force optical coherence elastography method (ARF-OCE) to evaluate the elastic properties of tissue. This method utilizes chirped acoustic radiation force to produce excitation along the sample's axial direction, and it uses phase-resolved optical coherence tomography (OCT) to measure the vibration of the sample. Under 500-Hz square wave modulated ARF signal excitation, phase change maps of tissue mimicking phantoms are generated by the ARF-OCE method, and the resulting Young's modulus ratio is correlated with a standard compression test. The results verify that this technique could efficiently measure sample elastic properties accurately and quantitatively. Furthermore, a three-dimensional ARF-OCE image of the human atherosclerotic coronary artery is obtained. The result indicates that our dynamic phase-resolved ARF-OCE method can delineate tissues with different mechanical properties.

Original languageEnglish (US)
Article number110505
JournalJournal of biomedical optics
Volume17
Issue number11
DOIs
StatePublished - Nov 2012

Keywords

  • Young's modulus
  • acoustic radiation force
  • atherosclerosis
  • elastography
  • mechanical properties
  • optical coherence tomography

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

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  • Cite this

    Qi, W., Chen, R., Chou, L., Liu, G., Zhang, J., Zhou, Q., & Chen, Z. (2012). Phase-resolved acoustic radiation force optical coherence elastography. Journal of biomedical optics, 17(11), [110505]. https://doi.org/10.1117/1.JBO.17.11.110505