Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors

Evan S. Deneris, John Connolly, Scott W. Rogers, Robert Duvoisin

Research output: Contribution to journalArticle

298 Citations (Scopus)

Abstract

Recent molecular cloning studies have identified several genes encoding α and β subunits of the nicotinic acetylcholine receptor. These genes have distinct, although overlapping, patterns of expression in the brain and peripheral ganglia. Multiple nicotinic receptors with distinct pharmacological and functional properties can be made in oocytes by pairwise combination of different α-type subunits with different β-type subunits. Both α and β subunits contribute to the pharmacological and functional diversity. Evan Deneris and colleagues explain how oocyte expression studies, in concert with immunological and electrophysiological analysis in vivo, are beginning to reveal the subunit compositions of different neuronal nicotinic receptor subtypes.

Original languageEnglish (US)
Pages (from-to)34-40
Number of pages7
JournalTrends in Pharmacological Sciences
Volume12
Issue numberC
DOIs
StatePublished - 1991
Externally publishedYes

Fingerprint

Nicotinic Receptors
Pharmacology
Oocytes
Gene encoding
Cloning
Molecular Cloning
Ganglia
Genes
Brain
Chemical analysis

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. / Deneris, Evan S.; Connolly, John; Rogers, Scott W.; Duvoisin, Robert.

In: Trends in Pharmacological Sciences, Vol. 12, No. C, 1991, p. 34-40.

Research output: Contribution to journalArticle

Deneris, Evan S. ; Connolly, John ; Rogers, Scott W. ; Duvoisin, Robert. / Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. In: Trends in Pharmacological Sciences. 1991 ; Vol. 12, No. C. pp. 34-40.
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