Abstract
Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors that belong to the steroid receptor superfamily. This family of PPARs includes PPARα, PPARδ, PPARγ1, and PPARγ2. These PPARs are related to the T3 and vitamin D3 receptors and bind to a hexameric direct repeat as a heterodimeric complex with retinoid receptor Xα. PPARs regulate the expression of a wide array of genes that encode proteins involved in lipid metabolism, energy balance, eicosanoid signaling, cell differentiation, and tumorigenesis. A unique feature of these steroid-like receptors is that the physiologic ligands for PPARs appear to be fatty acids from the n-6 and n-3 families of fatty acids and their respective eicosanoid products. This review describes the characteristics, regulation, and gene targets for PPARs and relates their effects on gene expression to physiologic outcomes that affect lipid and glucose metabolism, thermogenesis, atherosclerosis, and cell differentiation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 566-571 |
| Number of pages | 6 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 70 |
| Issue number | 4 |
| State | Published - Oct 1999 |
| Externally published | Yes |
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Keywords
- Differentiation
- Fat cells
- Fatty acid synthase
- Fatty acids
- Peroxisome proliferator-activated receptor
- Retinoid receptor Xα
- Review
- Transcription factor
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Food Science
Cite this
Peroxisome proliferator-activated receptors : A family of lipid-activated transcription factors. / Clarke, Steven D.; Thuillier, Philippe; Baillie, Rebecca A.; Sha, Xiaoming.
In: American Journal of Clinical Nutrition, Vol. 70, No. 4, 10.1999, p. 566-571.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peroxisome proliferator-activated receptors
T2 - A family of lipid-activated transcription factors
AU - Clarke, Steven D.
AU - Thuillier, Philippe
AU - Baillie, Rebecca A.
AU - Sha, Xiaoming
PY - 1999/10
Y1 - 1999/10
N2 - Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors that belong to the steroid receptor superfamily. This family of PPARs includes PPARα, PPARδ, PPARγ1, and PPARγ2. These PPARs are related to the T3 and vitamin D3 receptors and bind to a hexameric direct repeat as a heterodimeric complex with retinoid receptor Xα. PPARs regulate the expression of a wide array of genes that encode proteins involved in lipid metabolism, energy balance, eicosanoid signaling, cell differentiation, and tumorigenesis. A unique feature of these steroid-like receptors is that the physiologic ligands for PPARs appear to be fatty acids from the n-6 and n-3 families of fatty acids and their respective eicosanoid products. This review describes the characteristics, regulation, and gene targets for PPARs and relates their effects on gene expression to physiologic outcomes that affect lipid and glucose metabolism, thermogenesis, atherosclerosis, and cell differentiation.
AB - Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear transcription factors that belong to the steroid receptor superfamily. This family of PPARs includes PPARα, PPARδ, PPARγ1, and PPARγ2. These PPARs are related to the T3 and vitamin D3 receptors and bind to a hexameric direct repeat as a heterodimeric complex with retinoid receptor Xα. PPARs regulate the expression of a wide array of genes that encode proteins involved in lipid metabolism, energy balance, eicosanoid signaling, cell differentiation, and tumorigenesis. A unique feature of these steroid-like receptors is that the physiologic ligands for PPARs appear to be fatty acids from the n-6 and n-3 families of fatty acids and their respective eicosanoid products. This review describes the characteristics, regulation, and gene targets for PPARs and relates their effects on gene expression to physiologic outcomes that affect lipid and glucose metabolism, thermogenesis, atherosclerosis, and cell differentiation.
KW - Differentiation
KW - Fat cells
KW - Fatty acid synthase
KW - Fatty acids
KW - Peroxisome proliferator-activated receptor
KW - Retinoid receptor Xα
KW - Review
KW - Transcription factor
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UR - http://www.scopus.com/inward/citedby.url?scp=0032867442&partnerID=8YFLogxK
M3 - Article
C2 - 10500027
AN - SCOPUS:0032867442
VL - 70
SP - 566
EP - 571
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -