Abstract
Thyroid cancer is the most prevalent endocrine cancer whose incidence rates, particularly among women, have increased over the last decade. Although survival outcomes following surgery (with or without radioactive iodine ablation treatment) remain favorable, a significant proportion of patients are at lifetime risk of locoregional lymph node recurrence and distant metastasis. Serum thyroglobulin (Tg) has been the only circulating marker in routine use for detecting thyroid cancer recurrence, but it lacks sensitivity and is unreliable when Tg antibodies are present. New molecular markers for thyroid cancer have been investigated, with most based on detection in thyroid nodule or tumor tissue specimens. Recently, it has become possible to detect thyroid cancer cells in peripheral blood by measuring the mRNA of thyroid-specific genes, such as the mRNA of Tg and thyrotropin receptor. These have become promising new circulating markers for thyroid cancer. This review highlights the progress in this field from the perspective of improved initial cancer diagnosis and enhanced ability to monitor thyroid cancer recurrence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1415-1424 |
| Number of pages | 10 |
| Journal | Expert Review of Anticancer Therapy |
| Volume | 8 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2008 |
| Externally published | Yes |
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Keywords
- Messenger
- Neoplasm circulating cell
- Receptor
- Recurrence
- RNA
- Thyroglobulin
- Thyroid cancer
- Thyroid neoplasm
- Thyrotropin
- Tumor marker
ASJC Scopus subject areas
- Pharmacology (medical)
- Oncology
Cite this
Peripheral thyrotropin receptor mRNA as a novel marker for differentiated thyroid cancer diagnosis and surveillance. / Barbosa, German F.; Milas, Kresimira.
In: Expert Review of Anticancer Therapy, Vol. 8, No. 9, 2008, p. 1415-1424.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Peripheral thyrotropin receptor mRNA as a novel marker for differentiated thyroid cancer diagnosis and surveillance
AU - Barbosa, German F.
AU - Milas, Kresimira
PY - 2008
Y1 - 2008
N2 - Thyroid cancer is the most prevalent endocrine cancer whose incidence rates, particularly among women, have increased over the last decade. Although survival outcomes following surgery (with or without radioactive iodine ablation treatment) remain favorable, a significant proportion of patients are at lifetime risk of locoregional lymph node recurrence and distant metastasis. Serum thyroglobulin (Tg) has been the only circulating marker in routine use for detecting thyroid cancer recurrence, but it lacks sensitivity and is unreliable when Tg antibodies are present. New molecular markers for thyroid cancer have been investigated, with most based on detection in thyroid nodule or tumor tissue specimens. Recently, it has become possible to detect thyroid cancer cells in peripheral blood by measuring the mRNA of thyroid-specific genes, such as the mRNA of Tg and thyrotropin receptor. These have become promising new circulating markers for thyroid cancer. This review highlights the progress in this field from the perspective of improved initial cancer diagnosis and enhanced ability to monitor thyroid cancer recurrence.
AB - Thyroid cancer is the most prevalent endocrine cancer whose incidence rates, particularly among women, have increased over the last decade. Although survival outcomes following surgery (with or without radioactive iodine ablation treatment) remain favorable, a significant proportion of patients are at lifetime risk of locoregional lymph node recurrence and distant metastasis. Serum thyroglobulin (Tg) has been the only circulating marker in routine use for detecting thyroid cancer recurrence, but it lacks sensitivity and is unreliable when Tg antibodies are present. New molecular markers for thyroid cancer have been investigated, with most based on detection in thyroid nodule or tumor tissue specimens. Recently, it has become possible to detect thyroid cancer cells in peripheral blood by measuring the mRNA of thyroid-specific genes, such as the mRNA of Tg and thyrotropin receptor. These have become promising new circulating markers for thyroid cancer. This review highlights the progress in this field from the perspective of improved initial cancer diagnosis and enhanced ability to monitor thyroid cancer recurrence.
KW - Messenger
KW - Neoplasm circulating cell
KW - Receptor
KW - Recurrence
KW - RNA
KW - Thyroglobulin
KW - Thyroid cancer
KW - Thyroid neoplasm
KW - Thyrotropin
KW - Tumor marker
UR - http://www.scopus.com/inward/record.url?scp=55249098901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=55249098901&partnerID=8YFLogxK
U2 - 10.1586/14737140.8.9.1415
DO - 10.1586/14737140.8.9.1415
M3 - Article
VL - 8
SP - 1415
EP - 1424
JO - Expert Review of Anticancer Therapy
JF - Expert Review of Anticancer Therapy
SN - 1473-7140
IS - 9
ER -