Perception of inflation of a single lung lobe in humans

Robert B. Banzett, Steven Shea, Robert Brown, Richard Schwartzstein, Robert Lansing, Abraham Guz

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

We tested whether subjects could detect and localize inflation confined to a single lung lobe. A balloon-sealed catheter was placed into a lobar bronchus of unsedated subjects via fiberoptic bronchoscopy. Topical anesthesia (lidocaine) was used to suppress cough and irritation associated with inflation of the sealing balloon. Small (45-60 ml) or large (100-240 ml) stimulus volumes were insufflated via the catheter. In a forced-choice protocol, subjects were readily able to detect large inflations and correctly identify the side on which the stimulus was given, but small inflations were at the threshold of detection and were not correctly localized. Additional lidocaine applied to the bronchus in two subjects did not degrade detection. Circumstantial evidence suggests that the sensation arose in the lung. We conclude that this technique is feasible for the study of pulmonary perception.

Original languageEnglish (US)
Pages (from-to)125-136
Number of pages12
JournalRespiration Physiology
Volume107
Issue number2
DOIs
StatePublished - Feb 1997
Externally publishedYes

Fingerprint

Economic Inflation
Lung
Bronchi
Lidocaine
Catheters
Bronchoscopy
Cough
Anesthesia

Keywords

  • bronchoscopy
  • lung afferents
  • pulmonary stretch receptors
  • respiratory sensation
  • vagus nerve
  • visceral sensation

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

Cite this

Banzett, R. B., Shea, S., Brown, R., Schwartzstein, R., Lansing, R., & Guz, A. (1997). Perception of inflation of a single lung lobe in humans. Respiration Physiology, 107(2), 125-136. https://doi.org/10.1016/S0034-5687(96)02510-8

Perception of inflation of a single lung lobe in humans. / Banzett, Robert B.; Shea, Steven; Brown, Robert; Schwartzstein, Richard; Lansing, Robert; Guz, Abraham.

In: Respiration Physiology, Vol. 107, No. 2, 02.1997, p. 125-136.

Research output: Contribution to journalArticle

Banzett, RB, Shea, S, Brown, R, Schwartzstein, R, Lansing, R & Guz, A 1997, 'Perception of inflation of a single lung lobe in humans', Respiration Physiology, vol. 107, no. 2, pp. 125-136. https://doi.org/10.1016/S0034-5687(96)02510-8
Banzett, Robert B. ; Shea, Steven ; Brown, Robert ; Schwartzstein, Richard ; Lansing, Robert ; Guz, Abraham. / Perception of inflation of a single lung lobe in humans. In: Respiration Physiology. 1997 ; Vol. 107, No. 2. pp. 125-136.
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