Percent of prostate needle biopsy cores with cancer is a significant independent predictor of prostate specific antigen recurrence following radical prostatectomy: Results from the SEARCH database

Stephen J. Freedland, William J. Aronson, Martha K. Terris, Christopher J. Kane, Christopher Amling, Frederick Dorey, Joseph C. Presti

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Purpose: Recent studies have suggested that the percent of positive cores in the prostate needle biopsy is a significant predictor of outcome among men undergoing radical prostatectomy or radiation therapy for prostate cancer. We evaluate whether either percent of cores with cancer or percent of cores positive from the most and least involved side of the prostate needle biopsy was associated with a worse outcome among men treated with radical prostatectomy. Materials and Methods: A retrospective survey of 1,094 patients from the SEARCH Database treated with radical prostatectomy at 4 different equal access medical centers in California between 1988 and 2002 was undertaken. We used multivariate analysis to examine whether total percent of prostate needle biopsy cores with cancer, percent of cores positive from each side of the prostate and other clinical variables were significant predictors of adverse pathology and time to prostate specific antigen (PSA) recurrence following radical prostatectomy. Results: On multivariate analysis serum PSA and percent of positive cores were significant predictors of positive surgical margins, nonorgan confined disease and seminal vesicle invasion. Percent of positive cores (p

Original languageEnglish (US)
Pages (from-to)2136-2141
Number of pages6
JournalJournal of Urology
Volume169
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Large-Core Needle Biopsy
Prostate-Specific Antigen
Prostatectomy
Prostate
Databases
Recurrence
Needle Biopsy
Neoplasms
Multivariate Analysis
Seminal Vesicles
Prostatic Neoplasms
Radiotherapy
Pathology
Serum

Keywords

  • Biopsy, needle
  • Prostate-specific antigen, recurrence
  • Prostatectomy
  • Prostatic neoplasms

ASJC Scopus subject areas

  • Urology

Cite this

Percent of prostate needle biopsy cores with cancer is a significant independent predictor of prostate specific antigen recurrence following radical prostatectomy : Results from the SEARCH database. / Freedland, Stephen J.; Aronson, William J.; Terris, Martha K.; Kane, Christopher J.; Amling, Christopher; Dorey, Frederick; Presti, Joseph C.

In: Journal of Urology, Vol. 169, No. 6, 01.06.2003, p. 2136-2141.

Research output: Contribution to journalArticle

Freedland, Stephen J. ; Aronson, William J. ; Terris, Martha K. ; Kane, Christopher J. ; Amling, Christopher ; Dorey, Frederick ; Presti, Joseph C. / Percent of prostate needle biopsy cores with cancer is a significant independent predictor of prostate specific antigen recurrence following radical prostatectomy : Results from the SEARCH database. In: Journal of Urology. 2003 ; Vol. 169, No. 6. pp. 2136-2141.
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