Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection

Basel Assaf, Keith G. Mansfield, Susan V. Westmoreland, Amitinder Kaur, Kristie L. Oxford, Don J. Diamond, Peter A. Barry

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.

Original languageEnglish (US)
Pages (from-to)6354-6357
Number of pages4
JournalJournal of Virology
Volume86
Issue number11
DOIs
Publication statusPublished - Jun 2012
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Assaf, B., Mansfield, K. G., Westmoreland, S. V., Kaur, A., Oxford, K. L., Diamond, D. J., & Barry, P. A. (2012). Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection. Journal of Virology, 86(11), 6354-6357. https://doi.org/10.1128/JVI.00607-12