Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection

Basel T. Assaf; Keith G. Mansfield; Susan V. Westmoreland; Amitinder Kaur; Kristie L. Oxford; Don J. Diamond; Peter A. Barry

doi:10.1128/JVI.00607-12

Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection

Basel T. Assaf, Keith G. Mansfield, Susan V. Westmoreland, Amitinder Kaur, Kristie L. Oxford, Don J. Diamond, Peter A. Barry

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.

Original language	English (US)
Pages (from-to)	6354-6357
Number of pages	4
Journal	Journal of virology
Volume	86
Issue number	11
DOIs	https://doi.org/10.1128/JVI.00607-12
State	Published - Jun 2012
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Immunology
Insect Science
Virology

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title = "Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection",

abstract = "We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.",

author = "Assaf, {Basel T.} and Mansfield, {Keith G.} and Westmoreland, {Susan V.} and Amitinder Kaur and Oxford, {Kristie L.} and Diamond, {Don J.} and Barry, {Peter A.}",

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AU - Assaf, Basel T.

AU - Mansfield, Keith G.

AU - Westmoreland, Susan V.

AU - Kaur, Amitinder

AU - Oxford, Kristie L.

AU - Diamond, Don J.

AU - Barry, Peter A.

PY - 2012/6

Y1 - 2012/6

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AB - We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.

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Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV Infection

Abstract

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