Pattern of mucocutaneous manifestations in human immunodeficiency virus-positive patients in North India

Sachin Kore, Amrinder Kanwar, Keshavamurthy Vinay, Ajay Wanchu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Mucocutaneous diseases are among the first-recognized clinical manifestations of acquired immune deficiency syndrome. They function as visual markers in assessing the progression of human immunodeficiency virus (HIV) infection. Given the relative ease of examination of skin, its evaluation remains an important tool in the diagnosis of HIV infection. Objective: To determine the pattern of mucocutaneous manifestations in HIV-positive patients and to correlate their presence with CD4 counts. Materials and Methods: This cross-sectional study included 352 HIV-infected patients seen at PGIMER, Chandigarh, India, over a period of 1 year. The patients were screened for mucocutaneous disorders by an experienced dermatologist. The patients were classified into different stages according to the World Health Organization clinical and immunological staging system. Results: The most prevalent infection was candidiasis, seen in 57 patients (16.2%). Prevalence of candidiasis, dermatophytosis, herpes simplex, herpes zoster, molluscum contagiosum (MC), seborrheic dermatitis, adverse drug reaction, nail pigmentation, xerosis and diffuse hair loss differed statistically according to the clinical stages of HIV infection. There was a statistically significant association between immunological stages of HIV infection and dermatophytosis. Conclusion: Results of our study suggest that mucocutaneous findings occur throughout the course of HIV infection. Dermatoses like MC and dermatophytosis show an inverse relation with CD4 cell count, and these dermatoses can be used as a proxy indicator of advanced immunosuppression to start highly active anti-retroviral therapy in the absence of facilities to carry out CD4 cell count.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalIndian Journal of Sexually Transmitted Diseases
Volume34
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

Fingerprint

India
Virus Diseases
HIV
Tinea
CD4 Lymphocyte Count
Molluscum Contagiosum
Candidiasis
Skin Diseases
Seborrheic Dermatitis
Herpes Simplex
Alopecia
Pigmentation
Herpes Zoster
Proxy
Nails
Drug-Related Side Effects and Adverse Reactions
Immunosuppression
Acquired Immunodeficiency Syndrome
Cross-Sectional Studies
Skin

Keywords

  • Acquired immune deficiency syndrome
  • CD4 count
  • human immunodeficiency virus
  • India
  • mucocutaneous manifestation of AIDS

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Dermatology

Cite this

Pattern of mucocutaneous manifestations in human immunodeficiency virus-positive patients in North India. / Kore, Sachin; Kanwar, Amrinder; Vinay, Keshavamurthy; Wanchu, Ajay.

In: Indian Journal of Sexually Transmitted Diseases, Vol. 34, No. 1, 01.2013, p. 19-24.

Research output: Contribution to journalArticle

Kore, Sachin ; Kanwar, Amrinder ; Vinay, Keshavamurthy ; Wanchu, Ajay. / Pattern of mucocutaneous manifestations in human immunodeficiency virus-positive patients in North India. In: Indian Journal of Sexually Transmitted Diseases. 2013 ; Vol. 34, No. 1. pp. 19-24.
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