Patient-reported outcomes of brentuximab vedotin in Hodgkin lymphoma and anaplastic large-cell lymphoma

Robert Chen, Suzanne Allibone, Nancy L. Bartlett, Pauline Brice, Andy Chen, Katrina Pose, Lynn Rich, Vijay Bonthapally, Phillip M. Garfin, Michelle Fanale

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Background: Patients with relapsed/refractory (R/R) Hodgkin lymphoma (HL) or R/R systemic anaplastic large-cell lymphoma (sALCL) treated with brentuximab vedotin (BV) experienced high remission rates in two Phase II trials. With increased response rates and survival times, patient-reported outcomes (PROs) and health-related quality of life (HRQoL) are becoming increasingly important and can help inform treatment decisions to enhance care of cancer patients. Objective: The objective was to qualitatively assess HRQoL in long-term survivors treated with BV. Methods: An eight-question survey assessing PRO-related aspects was developed and fielded to a subset of patients with HL or sALCL who remained in long-term follow-up after completing BV treatment in the two pivotal studies. Results: The survey was completed by 25 of 38 patients (12 with HL, 13 with sALCL). The majority of patients reported that their energy level, outlook on life, difficulties with daily activities, ability to participate in physical activities, and overall HRQoL improved compared to those before BV treatment. Limitations: Small sample size and lack of a baseline questionnaire or validated assessment instrument limit broad applicability of these findings to large populations of patients with HL or sALCL. Conclusion: This is the first report of BV PRO data in R/R HL and sALCL. Given the patients’ poor prognostic outcomes before stem cell transplant, these encouraging results warrant formal evaluation of PRO end points in BV trials.

Original languageEnglish (US)
Pages (from-to)2027-2034
Number of pages8
JournalOncoTargets and Therapy
Volume9
DOIs
StatePublished - Apr 6 2016

Keywords

  • Activities of daily living
  • Brentuximab vedotin
  • Health-related quality of life
  • Patient well-being
  • Pilot study

ASJC Scopus subject areas

  • Oncology
  • Pharmacology (medical)

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    Chen, R., Allibone, S., Bartlett, N. L., Brice, P., Chen, A., Pose, K., Rich, L., Bonthapally, V., Garfin, P. M., & Fanale, M. (2016). Patient-reported outcomes of brentuximab vedotin in Hodgkin lymphoma and anaplastic large-cell lymphoma. OncoTargets and Therapy, 9, 2027-2034. https://doi.org/10.2147/OTT.S96175