Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics: Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study

Katharine Batt, Lisa Boggio, Anne Neff, Tyler W. Buckner, Michael Wang, Doris Quon, Michelle Witkop, Michael Recht, Craig Kessler, Neeraj N. Iyer, David L. Cooper

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Introduction: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. Objective: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. Methods: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. Results: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. Conclusions: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.

Original languageEnglish (US)
Pages (from-to)14-24
Number of pages11
JournalEuropean Journal of Haematology
Volume100
DOIs
StatePublished - Apr 1 2018

Fingerprint

Hemophilia A
Joints
Quality of Life
Pain
Arthralgia
Acute Pain
Chronic Pain
Anxiety
Depression
Unemployment
Joint Diseases
Health
Patient Reported Outcome Measures
Demography
Exercise
Hemorrhage
Equipment and Supplies

Keywords

  • coagulation disorders
  • quality of life

ASJC Scopus subject areas

  • Hematology

Cite this

Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics : Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. / Batt, Katharine; Boggio, Lisa; Neff, Anne; Buckner, Tyler W.; Wang, Michael; Quon, Doris; Witkop, Michelle; Recht, Michael; Kessler, Craig; Iyer, Neeraj N.; Cooper, David L.

In: European Journal of Haematology, Vol. 100, 01.04.2018, p. 14-24.

Research output: Contribution to journalArticle

Batt, Katharine ; Boggio, Lisa ; Neff, Anne ; Buckner, Tyler W. ; Wang, Michael ; Quon, Doris ; Witkop, Michelle ; Recht, Michael ; Kessler, Craig ; Iyer, Neeraj N. ; Cooper, David L. / Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics : Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study. In: European Journal of Haematology. 2018 ; Vol. 100. pp. 14-24.
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abstract = "Introduction: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. Objective: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. Methods: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. Results: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. Conclusions: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.",
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T2 - Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study

AU - Batt, Katharine

AU - Boggio, Lisa

AU - Neff, Anne

AU - Buckner, Tyler W.

AU - Wang, Michael

AU - Quon, Doris

AU - Witkop, Michelle

AU - Recht, Michael

AU - Kessler, Craig

AU - Iyer, Neeraj N.

AU - Cooper, David L.

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N2 - Introduction: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. Objective: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. Methods: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. Results: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. Conclusions: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.

AB - Introduction: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. Objective: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. Methods: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. Results: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. Conclusions: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.

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