TY - JOUR
T1 - Pathogenesis of glomerular injury in the fawn-hooded rat
T2 - Effect of unilateral nephrectomy
AU - Simons, Jacob L.
AU - Provoost, Abraham P.
AU - De Keijzer, Marinus H.
AU - Anderson, Sharon
AU - Rennke, Helmut G.
AU - Brenner, Barry M.
AU - Troy, Julia L.
AU - Zayas, Miguel A.
AU - Lee, Myriam
AU - Downes, Sandra J.
AU - Sandstrom, Deborah J.
AU - Van Aken, Matthijs
PY - 1993/12
Y1 - 1993/12
N2 - Fawn-hooded (FH) rats with congenital proteinuria and systemic and glomerular hypertension are very susceptible to renal damage at a young age. In this study, the effects of unilateral nephrectomy (UNX) on the function and structure of the remaining kidney in the FHH substrain were assessed. A long-term study was performed to determine the changes in systemic blood pressure, renal function, and proteinuria during the development of chronic renal failure in UNX-FHH and two-kidney (2K) FHH rats. Renal micropuncture and morphologic studies were performed at 4 wk after surgery. The long-term study showed that, after UNX, systolic blood pressure did not differ significantly from that of 2K-FHH rats. After UNX, there was compensatory hyperfiltration, at about 70% of the 2K level, that could be maintained for 12 wk only. The subsequent fall in GFR was preceded by severe proteinuria. The mean survival time of UNX-FHH rats was only 35 wk. Micropuncture studies showed that the high mean glomerular capillary pressure of 2K-FHH rats was further elevated after UNX. The glomerular capillary Ultrafiltration coefficient did not differ significantly between UNX-FHH and 2K-FHH rats. The weight of the remaining kidney and the mean glomerular tuft volume in UNX-FHH were, on average, 36 and 31% greater than in 2K rats. The results indicate that the FHH rat is extremely vulnerable to the adverse renal effects of UNX. A comparison of the hemodynamic and structural data of this study with those reported for other rat strains indicated that the severe glomerular hypertension, but not the degree of glomerular hypertrophy, underlies the high susceptibility to renal damage in UNX-FHH rats.
AB - Fawn-hooded (FH) rats with congenital proteinuria and systemic and glomerular hypertension are very susceptible to renal damage at a young age. In this study, the effects of unilateral nephrectomy (UNX) on the function and structure of the remaining kidney in the FHH substrain were assessed. A long-term study was performed to determine the changes in systemic blood pressure, renal function, and proteinuria during the development of chronic renal failure in UNX-FHH and two-kidney (2K) FHH rats. Renal micropuncture and morphologic studies were performed at 4 wk after surgery. The long-term study showed that, after UNX, systolic blood pressure did not differ significantly from that of 2K-FHH rats. After UNX, there was compensatory hyperfiltration, at about 70% of the 2K level, that could be maintained for 12 wk only. The subsequent fall in GFR was preceded by severe proteinuria. The mean survival time of UNX-FHH rats was only 35 wk. Micropuncture studies showed that the high mean glomerular capillary pressure of 2K-FHH rats was further elevated after UNX. The glomerular capillary Ultrafiltration coefficient did not differ significantly between UNX-FHH and 2K-FHH rats. The weight of the remaining kidney and the mean glomerular tuft volume in UNX-FHH were, on average, 36 and 31% greater than in 2K rats. The results indicate that the FHH rat is extremely vulnerable to the adverse renal effects of UNX. A comparison of the hemodynamic and structural data of this study with those reported for other rat strains indicated that the severe glomerular hypertension, but not the degree of glomerular hypertrophy, underlies the high susceptibility to renal damage in UNX-FHH rats.
KW - Chronic renal failure
KW - Focal and segmental glomerular sclerosis
KW - GFR
KW - Glomerular capillary hydraulic pressure
KW - Proteinuria
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M3 - Article
C2 - 8130363
AN - SCOPUS:0027765104
SN - 1046-6673
VL - 4
SP - 1362
EP - 1370
JO - Journal of the American Society of Nephrology
JF - Journal of the American Society of Nephrology
IS - 6
ER -