Pathogenesis of glomerular injury in the fawn-hooded rat: Effect of unilateral nephrectomy

Jacob L. Simons, Abraham P. Provoost, Marinus H. De Keijzer, Sharon Anderson, Helmut G. Rennke, Barry M. Brenner, Julia L. Troy, Miguel A. Zayas, Myriam Lee, Sandra J. Downes, Deborah J. Sandstrom, Matthijs Van Aken

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Fawn-hooded (FH) rats with congenital proteinuria and systemic and glomerular hypertension are very susceptible to renal damage at a young age. In this study, the effects of unilateral nephrectomy (UNX) on the function and structure of the remaining kidney in the FHH substrain were assessed. A long-term study was performed to determine the changes in systemic blood pressure, renal function, and proteinuria during the development of chronic renal failure in UNX-FHH and two-kidney (2K) FHH rats. Renal micropuncture and morphologic studies were performed at 4 wk after surgery. The long-term study showed that, after UNX, systolic blood pressure did not differ significantly from that of 2K-FHH rats. After UNX, there was compensatory hyperfiltration, at about 70% of the 2K level, that could be maintained for 12 wk only. The subsequent fall in GFR was preceded by severe proteinuria. The mean survival time of UNX-FHH rats was only 35 wk. Micropuncture studies showed that the high mean glomerular capillary pressure of 2K-FHH rats was further elevated after UNX. The glomerular capillary Ultrafiltration coefficient did not differ significantly between UNX-FHH and 2K-FHH rats. The weight of the remaining kidney and the mean glomerular tuft volume in UNX-FHH were, on average, 36 and 31% greater than in 2K rats. The results indicate that the FHH rat is extremely vulnerable to the adverse renal effects of UNX. A comparison of the hemodynamic and structural data of this study with those reported for other rat strains indicated that the severe glomerular hypertension, but not the degree of glomerular hypertrophy, underlies the high susceptibility to renal damage in UNX-FHH rats.

Original languageEnglish (US)
Pages (from-to)1362-1370
Number of pages9
JournalJournal of the American Society of Nephrology
Issue number6
StatePublished - Dec 1993
Externally publishedYes


  • Chronic renal failure
  • Focal and segmental glomerular sclerosis
  • GFR
  • Glomerular capillary hydraulic pressure
  • Proteinuria

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Pathogenesis of glomerular injury in the fawn-hooded rat: Effect of unilateral nephrectomy'. Together they form a unique fingerprint.

Cite this