Patellins 1-6 and trunkamide A: Novel cyclic hexa-, hepta- and octa-peptides from colonial ascidians, Lissoclinum sp

Anthony R. Carroll, John C. Coll, David J. Bourne, John K. MacLeod, T. Mark Zabriskie, Chris M. Ireland, Bruce F. Bowden

Research output: Contribution to journalArticlepeer-review

78 Scopus citations

Abstract

Patellins 1-5 have been isolated from the colonial ascidian Lissoclinum patella from Viti Levu, Fiji. Patellins 1 and 2 are cyclic hexapeptides, while patellins 3-5 are cyclic octapeptides. Two of these peptides (patellins 3 and 5), a new cyclic octapeptide (patellin 6), a new cyclic heptapeptide (trunkamide A), and the known metabolite lissoclinolide have also been isolated from a Lissoclinum sp. collected on the Great Barrier Reef, Australia. All structures were determined by high-field n.m.r. and mass spectroscopic methods, and by h.p.l.c. analysis of the constituent amino acids after hydrolysis of the peptides and derivatization according to Marfey's procedure.

Original languageEnglish (US)
Pages (from-to)659-667
Number of pages9
JournalAustralian Journal of Chemistry
Volume49
Issue number6
DOIs
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)

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